HOME >> BIOLOGY >> NEWS
Cold Virus With P53 Gene Tested To Combat Ovarian Cancer

DALLAS - October 28, 1998 - Researchers at UT Southwestern Medical Center at Dallas are using the p53 gene, inserted into an inactive common-cold virus, as a novel way to attack ovarian cancer in a patient.

Drs. Carolyn Muller and Robert Coleman, assistant professors of obstetrics and gynecology, said p53 is known as the housekeeper gene because it patrols for damaged cells, and if the cells cannot be repaired or are growing out of control and can't be contained, the p53 gene turns on its second line of defense: a built-in cell-death program, a process called apoptosis. The p53 mutations are the most common mutations in solid tumors and are found in 50 percent to 79 percent of ovarian cancers.

Muller said the normal p53 genes are replicated in the laboratory and inserted into adenoviruses, which act as carriers. During the treatment procedure, the patient's large amount of abdominal fluids, caused by the cancer, is withdrawn, and a therapeutic mixture of engineered p53 genes floating in saline is injected into the abdominal cavity. There the viral "geneboats" deliver the p53 gene to all cells. Once the gene is turned on in cancer cells, the invading "housekeeper" goes to work, recognizes the cancer cell's DNA damage and condemns it to death.

Muller and Coleman, who work in the Harold C. Simmons Comprehensive Cancer Center and the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, said that this trial will determine several things. They include the appropriate mixture of engineered viruses in the solution, the sequence of doses, the length of treatment and the manner in which the patient reacts to it. The first patient's treatments are occurring in three weekly visits with two-week intervals between them. Patients will continue treatments as long as a positive response occurs unless significant side effects develop. Fifteen to 18 patients are expected to be treated in this study.

Nancy Ruff, a 65-year-old wife, mother and grand
'"/>

Contact: Ann Harrell
ann.harrell@email.swmed.edu
214-648-3404
UT Southwestern Medical Center
28-Oct-1998


Page: 1 2

Related biology news :

1. Virus known for its photo ops makes its movie screen debut
2. Viruses clear bacterial contamination in chickens
3. Viruses may be environmentally friendly decontaminants
4. The Virus-Cancer Link: Examining the Role of Viruses in the Development of Cancer
5. Virus researchers close in on the secret life of DNA
6. Virus beats food bug
7. West Nile Virus cases analyzed for prevalence and symptoms
8. West Nile Virus can cause polio-like symptoms
9. Antibodies critical for fighting West Nile Virus infection
10. CDC Telebriefing: Smallpox educational activities and West Nile Virus update
11. West Nile Virus capsid protein causes encephalitic inflammation by triggering cell suicide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... ... May 07, 2019 , ... ... accepted into Forbes Technology Council, an invitation-only community for world-class CIOs, CTOs, ... a full-service biopharmaceutical cold chain engineering firm that guarantees confidence in a ...
(Date:5/7/2019)... ... 2019 , ... Landsec and Spartan Bioscience today announced they ... In May, Landsec will undertake trials using Spartan’s innovative Legionella test. Spartan’s test ... corrective action within hours instead of weeks. This test, if approved, could ...
(Date:5/2/2019)... ... 01, 2019 , ... uBiome, the leader in microbial genomics, ... General Counsel, as Interim Chief Executive Officer of uBiome, effective immediately. The Company’s ... There will also be an independent investigation into uBiome’s billing practices to be ...
Breaking Biology News(10 mins):
(Date:4/15/2019)... LOVELAND, Ohio (PRWEB) , ... April 15, 2019 ... ... and oligomers, has completed construction of a $2 million bench plant expansion to ... represents an important step in the design and construction of Sirrus’ full-scale production ...
(Date:4/10/2019)... ... April 10, 2019 , ... After more than three months of ... kitchen is equipped with updated appliances and modern lighting and fixtures, and will provide ... , “We’ve seen tremendous growth in the demand for our team-building events and ...
(Date:4/9/2019)... ... 2019 , ... The American Society of Gene & Cell Therapy (ASGCT) ... a new addition to the presidential line of succession, at the 22nd Annual ... leadership team for a three-year term (2019-2021). , All five incoming members of the ...
(Date:4/8/2019)... Zealand (PRWEB) , ... April 09, 2019 , ... ... infectious disease, the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has ... study of antibody repertoires is part of CZ Biohub’s efforts to establish new ...
Breaking Biology Technology:
Cached News: