Collaboration to use proteomics to unravel mysteries of hea...( DURHAM N.C. -- Researchers from Duke U...)

DURHAM, N.C. -- Researchers from Duke University Medical Center; GeneProt, Inc., Geneva, Switzerland; and Novartis Pharma AG, Basel, Switzerland have launched a collaboration to identify how the proteins produced by heart disease patients differ from those of healthy people. Their research, which uses an industrial-scale approach to protein analysis and unusually large volumes of blood, could yield information that leads to new drugs or other treatments for coronary artery disease.

The researchers will compare blood samples from heart disease patients and normal people to detect subtle differences in the proteomes of the two groups. The proteome comprises the total number of proteins in an organism, much as a genome comprises its genes.

"This study is a new approach to unraveling the mysteries of the world's No. 1 health problem," said Duke's Chris Granger, a cardiologist at the Duke Clinical Research Institute and lead Duke investigator for the study.

"Although the sequencing of the human genome was heralded as one of science's greatest accomplishments, studies such as this one are essential for determining how the code of life produces the specific proteins that play a role in heart disease," Granger continued.

"This important project links the sophisticated capabilities of GeneProt in proteomic technologies, bioinformatics and protein synthesis to the exquisitely detailed patient phenotypes provided by Duke's unique Databank for Cardiovascular Diseases," said Sandy Williams, M.D., dean of the Duke University School of Medicine and vice chancellor for health affairs at Duke University Medical Center. "I believe this collaboration among Novartis, GeneProt and Duke University, under the leadership of Chris Granger, is a model for academic/industry relationships that will benefit our patients in the coming decade".

To assemble ideal comparison groups with and without coronary artery disease, the research team searched through t
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Contact: Richard Merritt
merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
3-Sep-2002

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