e to know how the cancer is accomplishing this. At the UW, previous studies have determined that many men, even those who are subsequently cured with local therapy, appear to have prostate cancer cells in their blood and bone marrow very early in the disease process. It is not known why some of these cells turn into deadly metastatic cancer, while others remain dormant or die.

In 2003, the UW will move its urology and prostate treatment center into new quarters at the UW Medical Center Surgery Pavilion, now under construction. The UW and the FHCRC recently launched a joint fund-raising campaign to establish the Prostate Cancer Research Institute, which will include researchers from both institutions. Through the new institute, the UW and FHCRC will work together to accelerate the search for a cure for this disease.

Details about the grant and projects begin on the next page.

Backgrounder

National Cancer Institute Program Project Grant:
Mechanisms and Markers of Prostate Cancer Metastases

Amounts (total $10.5 million)
- University of Washington: $5.5 million
- Fred Hutchinson Cancer Research Center: $2.7 million
- Institute for Systems Biology: $2.3 million

Projects

Project 1: New Molecular Markers of Progressive Disease
Project manager: Dr. Leroy Hood, co-founder and president, Institute for Systems Biology, and UW affiliate professor of bioengineering, immunology, and computer science and engineering.

Researchers in Seattle already have a large collection of prostate cancer cells, including cell lines that vary by low, intermediate or high virulence. The researchers have already analyzed genes involved in the progression of prostate cancer. In this part of the program project grant, researchers will continue their search for genes that could be diagnostic markers and therapeutic targets. They hope to identify at least 12 "gene
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Contact: Walter Neary
wneary@u.washington.edu
206-685-3841
University of Washington
17-Jul-2002

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