HOME >> BIOLOGY >> NEWS
Colorado State microbiologists help identify cell membrane substance that could,,'boost' vaccines for tuberculosis, other diseases

FORT COLLINS--Two Colorado State University microbiologists have helped identify a substance produced by the tuberculosis bacterium that triggers an immune response in the human body.

The finding suggests that the substance in combination with vaccines could serve to enhance the ability of the bodies' immune response to fight tuberculosis and other microbial infections.

A report of the finding, published Friday in the journal Science, includes among its authors Patrick Brennan, professor of microbiology, and John Belisle, assistant professor of microbiology.

Working with researchers from UCLA and a number of other institutions, the Colorado State investigators undertook the specific task of identifying the lipoprotein, a molecule combining fat-like materials with protein, found in the cell walls of Mycobacterium tuberculosis.

"Our role (at Colorado State) was actually in isolating the lipoprotein molecule from the tuberculosis bacilli, purifying it and then working closely with the UCLA group to show that this is what was stimulating interleukin-12 production," Belisle said. Interleukin-12, produced by the human body, initiates a cascade of chemicals that activate production of more white blood cells to combat invading bacteria.

"In practical terms, we think we may have isolated a natural adjuvant (vaccine booster) that can be included with subunit vaccines (those made with parts of bacteria, such as proteins) to push the immune system in the right direction," Belisle said.

By isolating and concentrating the lipoprotein producing the strongest reaction, Belisle and Brennan hope to add it to vaccines under development, including one by a Colorado State research team led by microbiologist Ian Orme. The combined effect should provide immunity against the growing threat of tuberculosis, which is affecting urbanites in underdeveloped areas, prison populations and those with alread
'"/>

Contact: David Weymiller
dweymiller@vines.colostate.edu
970-491-6851
Colorado State University
30-Jul-1999


Page: 1 2 3

Related biology news :

1. Colorado River Conference Aug. 26
2. Hidden cost of Colorado River diversions is $2.4 billion annually
3. Earstones tell fishes tale of early life in the Colorado River estuary
4. U. of Colorado professor pioneering tissue engineering from knees to hearts to brains
5. University of Colorado archaeologist, colleagues hot on the trail of ancient Persian warships
6. U. of Colorado team developing Flu Chip for fast, accurate diagnosis
7. Microbes active in Colorado snows fuel tundra ecosystem
8. New Colorado U. study shows increase in fungal metabolism under the snow
9. Changing global nitrogen cycle impacting human health, says Colorado University-led study
10. U. of Colorado scientists discover four new kingdoms of life
11. U.of Colorado researchers solve molecular structure involved with heart disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
Breaking Biology Technology:
Cached News: