HOME >> BIOLOGY >> NEWS
Colorado State microbiologists help identify cell membrane substance that could,,'boost' vaccines for tuberculosis, other diseases

FORT COLLINS--Two Colorado State University microbiologists have helped identify a substance produced by the tuberculosis bacterium that triggers an immune response in the human body.

The finding suggests that the substance in combination with vaccines could serve to enhance the ability of the bodies' immune response to fight tuberculosis and other microbial infections.

A report of the finding, published Friday in the journal Science, includes among its authors Patrick Brennan, professor of microbiology, and John Belisle, assistant professor of microbiology.

Working with researchers from UCLA and a number of other institutions, the Colorado State investigators undertook the specific task of identifying the lipoprotein, a molecule combining fat-like materials with protein, found in the cell walls of Mycobacterium tuberculosis.

"Our role (at Colorado State) was actually in isolating the lipoprotein molecule from the tuberculosis bacilli, purifying it and then working closely with the UCLA group to show that this is what was stimulating interleukin-12 production," Belisle said. Interleukin-12, produced by the human body, initiates a cascade of chemicals that activate production of more white blood cells to combat invading bacteria.

"In practical terms, we think we may have isolated a natural adjuvant (vaccine booster) that can be included with subunit vaccines (those made with parts of bacteria, such as proteins) to push the immune system in the right direction," Belisle said.

By isolating and concentrating the lipoprotein producing the strongest reaction, Belisle and Brennan hope to add it to vaccines under development, including one by a Colorado State research team led by microbiologist Ian Orme. The combined effect should provide immunity against the growing threat of tuberculosis, which is affecting urbanites in underdeveloped areas, prison populations and those with alread
'"/>

Contact: David Weymiller
dweymiller@vines.colostate.edu
970-491-6851
Colorado State University
30-Jul-1999


Page: 1 2 3

Related biology news :

1. Colorado River Conference Aug. 26
2. Hidden cost of Colorado River diversions is $2.4 billion annually
3. Earstones tell fishes tale of early life in the Colorado River estuary
4. U. of Colorado professor pioneering tissue engineering from knees to hearts to brains
5. University of Colorado archaeologist, colleagues hot on the trail of ancient Persian warships
6. U. of Colorado team developing Flu Chip for fast, accurate diagnosis
7. Microbes active in Colorado snows fuel tundra ecosystem
8. New Colorado U. study shows increase in fungal metabolism under the snow
9. Changing global nitrogen cycle impacting human health, says Colorado University-led study
10. U. of Colorado scientists discover four new kingdoms of life
11. U.of Colorado researchers solve molecular structure involved with heart disease

Post Your Comments:
(Date:7/29/2014)... UK overseas territory of Ascension Island, one of the ... a renaissance. , Writing in the journal Biodiversity ... and Ascension Island Government Conservation Department report that the ... Atlantic outpost has increased by more than 500 per ... as 24,000 nests are now estimated to be laid ...
(Date:7/29/2014)... Schools of Dentistry (UM SOD) and Medicine (UM ... a five-year $10.7 million grant award from the ... of the National Institutes of Health to study ... (STDs). The grant, which renews a previous $12 ... direction for the research by studying chlamydial and ...
(Date:7/29/2014)... for parents of preterm babies latest research from the ... they become teenagers, the brains of many preterm children can ... A study conducted by the University,s Robinson Research Institute ... experiences no brain injury in early life, their cognitive abilities ... term-born peers. , However, the results of the study, published ...
Breaking Biology News(10 mins):Major turtle nesting beaches protected in 1 of the UK's far flung overseas territories 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Preterm children's brains can catch up years later 2
(Date:7/29/2014)... 2014 “PharmaSphere: Emerging Biotech Investment ... Capital Funding” report provides in-depth analysis of the ... and venture capital segments of the financial industry, ... have significant impact on the future of emerging ... the report identifies regions of the world that ...
(Date:7/29/2014)... 2014 Human Longevity, Inc. (HLI), a genomics ... extending the healthy, high performance human life span, today ... an expert in machine learning and machine translation as ... from Google where he was Distinguished Research Scientist and ... to HLI Co-Founder and CEO, J. Craig Venter ...
(Date:7/29/2014)... July 29, 2014  The Society for Clinical ... updated program for the 9 th annual ... in Amelia Island , Florida.  The focus ... remains unchanged, however, the topics and format will ... opportunity among all stakeholders with a continued focus ...
(Date:7/29/2014)... , July 29, 2014  Discovery Laboratories, Inc. ... advancing a new standard of respiratory critical care, will ... August 5, 2014 before the open of the ... will host a live teleconference and webcast at ... conference call, Discovery Labs, management will discuss the ...
Breaking Biology Technology:Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3Discovery Labs to Report 2014 Second Quarter Financial Results and Hold Conference Call on Tuesday, August 5, 2014 at 9:00 a.m. Eastern Time 2
Cached News: