Colorado State microbiologists help identify cell membrane substance that could,,'boost' vaccines for tuberculosis, other diseases

FORT COLLINS--Two Colorado State University microbiologists have helped identify a substance produced by the tuberculosis bacterium that triggers an immune response in the human body.

The finding suggests that the substance in combination with vaccines could serve to enhance the ability of the bodies' immune response to fight tuberculosis and other microbial infections.

A report of the finding, published Friday in the journal Science, includes among its authors Patrick Brennan, professor of microbiology, and John Belisle, assistant professor of microbiology.

Working with researchers from UCLA and a number of other institutions, the Colorado State investigators undertook the specific task of identifying the lipoprotein, a molecule combining fat-like materials with protein, found in the cell walls of Mycobacterium tuberculosis.

"Our role (at Colorado State) was actually in isolating the lipoprotein molecule from the tuberculosis bacilli, purifying it and then working closely with the UCLA group to show that this is what was stimulating interleukin-12 production," Belisle said. Interleukin-12, produced by the human body, initiates a cascade of chemicals that activate production of more white blood cells to combat invading bacteria.

"In practical terms, we think we may have isolated a natural adjuvant (vaccine booster) that can be included with subunit vaccines (those made with parts of bacteria, such as proteins) to push the immune system in the right direction," Belisle said.

By isolating and concentrating the lipoprotein producing the strongest reaction, Belisle and Brennan hope to add it to vaccines under development, including one by a Colorado State research team led by microbiologist Ian Orme. The combined effect should provide immunity against the growing threat of tuberculosis, which is affecting urbanites in underdeveloped areas, prison populations and those with alread

Contact: David Weymiller
Colorado State University

Page: 1 2 3

Related biology news :

1. Colorado River Conference Aug. 26
2. Hidden cost of Colorado River diversions is $2.4 billion annually
3. Earstones tell fishes tale of early life in the Colorado River estuary
4. U. of Colorado professor pioneering tissue engineering from knees to hearts to brains
5. University of Colorado archaeologist, colleagues hot on the trail of ancient Persian warships
6. U. of Colorado team developing Flu Chip for fast, accurate diagnosis
7. Microbes active in Colorado snows fuel tundra ecosystem
8. New Colorado U. study shows increase in fungal metabolism under the snow
9. Changing global nitrogen cycle impacting human health, says Colorado University-led study
10. U. of Colorado scientists discover four new kingdoms of life
11. U.of Colorado researchers solve molecular structure involved with heart disease

Post Your Comments:

(Date:5/23/2017)... 23, 2017  Hunova, the first robotic gym for the rehabilitation and ... launched in Genoa, Italy . The first 30 robots ... the USA . The technology was developed and patented ... the IIT spin-off Movendo Technology thanks to a 10 million euro investment ... please click: ...
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research ... Inc. has been selected for membership in ARCS Alumni Hall of Fame ...
(Date:10/11/2017)... ... 2017 , ... Personal eye wash is a basic first aid supply for any work environment, ... eye do you rinse first if a dangerous substance enters both eyes? It’s one less ... with its unique dual eye piece. , “Whether its dirt and debris, or an acid ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... it will be hosting a Webinar titled, “Pathology is going digital. Is your ... on digital pathology adoption best practices and how Proscia improves lab economics and ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
Breaking Biology Technology:
Cached News: