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Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say

s with labeled A2E to identify its specific cellular targets.

"Our overall goal is to understand the effects of A2E on cell function," Dr. Parish said. "Does it cause AMD directly" What are the chemical and biochemical bases for the disease" And does that knowledge lend itself to measures that could prevent or cure the disease?"

The work was supported by a National Institutes of Health grant to Professor Nakanishi, an NIH postdoctoral fellowship to Dr. Parish and an unrestricted grant from Research to Prevent Blindness to Columbia's Department of Ophthalmology.

This document is available at http://www.columbia.edu/cu/pr/. Working press may receive science and technology press releases via e-mail by sending a message to rjn2@columbia.edu.


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Contact: Bob Nelson
rjn2@columbia.edu
212-854-6580
Columbia University
7-Dec-1998


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