HOME >> BIOLOGY >> NEWS
Combination Therapy For Brain Tumors Holds Promise For Longer Survival After,,Surgery

Combination Therapy for Brain Tumors Holds Promise for Longer Survival After Surgery Despite advances in neuroimaging and surgery, no major developments in the treatment of malignant brain tumors have been introduced in the past two decades. Right now, surgeons rely on radiation therapy after removal of the tumor to mop up microscopic cancerous cells that could lead to regrowth. Brain tumors, however, are extremely resistant to radiation treatment. Researchers at the University of Pennsylvania Medical Center have now found a way to make brain cancer cells more receptive to radiation treatment --by 60-fold in some cases.

"The goal of our research is to extend the survival of terminally ill patients and give them a better quality of life during that time," says Donald M. O'Rourke, MD, assistant professor of neurosurgery. "Following a diagnosis of brain cancer, median survival of patients is only 12 months with treatment." More than 17,000 new cases of brain cancer are reported each year, according to O'Rourke, and this diagnosis is nearly always fatal.

In a biochemical one-two punch to brain cancer cells, O'Rourke and colleagues inactivated a common cell-surface receptor called the Epidermal Growth Factor Receptor (or erbB for short) to arrest cell growth in human cell lines, which further sensitized the cells to radiation. This approach works in a similar way to Herceptin, the new breast-cancer-fighting drug awaiting FDA approval. Herceptin, a monoclonal antibody therapy, is based on the basic research performed by the laboratory of Mark I. Greene, MD, PhD, at Penn. Both strategies target mutated or overexpressed erbB receptor proteins that allow cancer cells to grow unchecked.

"Depending on which type of cell we used, we achieved between 20 and 60 percent cell death in cancer cells where the erbB receptor was first deactivated, versus zero to 5 percent in radiation-alone controls," reports O'Rourke. These findings were pu
'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
(215) 614-0290
University of Pennsylvania School of Medicine
16-Sep-1998


Page: 1 2

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy dramatically improves function after spinal cord injury in rats
3. Combination therapy drives cancer into remission
4. Combination drug therapy drastically reduces multiple coronary heart disease risk factors
5. Combination therapy improves anthrax survival
6. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. 1st International Conference on Cell Therapy for Cardiovascular Disease
10. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
11. Braunschweig Prize 2003 for Molecular Cancer Therapy

Post Your Comments:
(Date:3/2/2015)... , March 2, 2015  Businesses have ... Data protection company Tharon Rankins Enterprises has announced ... provides an ultra-safe way for businesses to protect ... financial transactions. Beconux is a ... Rankins Enterprises. Functioning similarly to an ATM machine, ...
(Date:2/24/2015)... -- This report analyzes the worldwide markets for Iris Biometrics ... the US, Canada , Japan ... , Middle East , and ... provided for the period 2013 through 2020. Also, a seven-year ... analytics are derived from primary and secondary research. Company profiles ...
(Date:2/23/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... for DISTRIBUTED VOICE DIRECTED PAYMENT METHOD AND ... new groundbreaking payment method. Payment accounts may be selected ... be accessed if both the speech (the word associated ...
Breaking Biology News(10 mins):Personal Data Protection Company Launches New Product 2World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
(Date:3/3/2015)... March 3, 2015 Adaptive Biotechnologies announced today ... joining its Board of Director as Chair of the ... Zillow Group, Chad oversees all finance, treasury and accounting ... company,s core finance, treasury and accounting functions, and led ... acquisitions. In 2013, he was named Puget Sound Business ...
(Date:3/3/2015)... YORK , March 3, 2015 Fried, ... Jeffrey I.D. Lewis has joined the Firm ... resident in the New York ... handles trademark matters, as well as other intellectual property ... patent attorney, Mr. Lewis represents both plaintiffs and defendants ...
(Date:3/3/2015)... 3, 2015  Thingee Corporation, a software development company ... presentation entitled, "Technology Adoption: Making Reps, Lives Easier" during ... and Technology ,  in Deerfield Beach, Florida ... 2015. Audiences looking to learn how technology can help ... be in the audience for the Thingee presentation. ...
(Date:3/3/2015)... Liberty Corner, New Jersey (PRWEB) March 03, 2015 ... in NJ, has announced today that it has ... DE. Terms of the transaction were not ... engineering consulting services to the energy sector including ... gas, alternative energy, and fossil and nuclear power ...
Breaking Biology Technology:Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 3Thingee to present at 11th Annual Synergistix Users Conference 2
Cached News: