HOME >> BIOLOGY >> NEWS
Combination Therapy For Brain Tumors Holds Promise For Longer Survival After,,Surgery

Combination Therapy for Brain Tumors Holds Promise for Longer Survival After Surgery Despite advances in neuroimaging and surgery, no major developments in the treatment of malignant brain tumors have been introduced in the past two decades. Right now, surgeons rely on radiation therapy after removal of the tumor to mop up microscopic cancerous cells that could lead to regrowth. Brain tumors, however, are extremely resistant to radiation treatment. Researchers at the University of Pennsylvania Medical Center have now found a way to make brain cancer cells more receptive to radiation treatment --by 60-fold in some cases.

"The goal of our research is to extend the survival of terminally ill patients and give them a better quality of life during that time," says Donald M. O'Rourke, MD, assistant professor of neurosurgery. "Following a diagnosis of brain cancer, median survival of patients is only 12 months with treatment." More than 17,000 new cases of brain cancer are reported each year, according to O'Rourke, and this diagnosis is nearly always fatal.

In a biochemical one-two punch to brain cancer cells, O'Rourke and colleagues inactivated a common cell-surface receptor called the Epidermal Growth Factor Receptor (or erbB for short) to arrest cell growth in human cell lines, which further sensitized the cells to radiation. This approach works in a similar way to Herceptin, the new breast-cancer-fighting drug awaiting FDA approval. Herceptin, a monoclonal antibody therapy, is based on the basic research performed by the laboratory of Mark I. Greene, MD, PhD, at Penn. Both strategies target mutated or overexpressed erbB receptor proteins that allow cancer cells to grow unchecked.

"Depending on which type of cell we used, we achieved between 20 and 60 percent cell death in cancer cells where the erbB receptor was first deactivated, versus zero to 5 percent in radiation-alone controls," reports O'Rourke. These findings were pu
'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
(215) 614-0290
University of Pennsylvania School of Medicine
16-Sep-1998


Page: 1 2

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy dramatically improves function after spinal cord injury in rats
3. Combination therapy drives cancer into remission
4. Combination drug therapy drastically reduces multiple coronary heart disease risk factors
5. Combination therapy improves anthrax survival
6. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. 1st International Conference on Cell Therapy for Cardiovascular Disease
10. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
11. Braunschweig Prize 2003 for Molecular Cancer Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/23/2020)... ... April 23, 2020 , ... Despite ... MDG provides critical infrastructure products for the animal feed, human consumption, wastewater, and ... expansion. Further, as supply channels from overseas competitors have become weakened or shut ...
(Date:4/22/2020)... ... April 21, 2020 , ... ... leveraged venture capital firm that provides patent development support for early stage startups. ... treat illnesses such as ovarian cancer and precancerous pancreatic lesions with simple, accurate ...
(Date:4/22/2020)... ... April 21, 2020 , ... Worcester Polytechnic Institute (WPI) is ... critical medical supplies to address the expected spike of COVID-19 cases. As part of ... has arranged for 3D printers and other materials to be sent to six countries ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... , ... May 14, 2020 , ... This new service ... and the most pressing questions answered quickly as the need arises. Lachman’s OnCall SMEs ... valuable advice at affordable rates. , Lachman OnCall™ SMEs are available normal business ...
(Date:5/14/2020)... Del. (PRWEB) , ... May 12, 2020 , ... ... of Interdisp JCS as the new distribution partner for all personal care ingredients ... DuPont GENENCARE®OSMS portfolio and DuPont preservative portfolio for personal care. , The ...
(Date:5/14/2020)... ... May 13, 2020 , ... In ... Lab: Optimizing Workflows in the Life Science Lab . The comprehensive information source ... from water purification and liquid handling to contamination control. , The content hub ...
(Date:5/9/2020)... ... ... Worldwide Business with kathy ireland® will be LIVE streaming ... and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime time ... Techolution and Bravado Pharmaceuticals . , As leaders in their ...
Breaking Biology Technology:
Cached News: