HOME >> BIOLOGY >> NEWS
Combination Therapy For Brain Tumors Holds Promise For Longer Survival After,,Surgery

blished in a September issue of the Proceedings of the National Academy of Sciences.

ErbB receptors are a family of four proteins and are widely expressed in many tumors; but, when mutated or overexpressed at very high levels, lead to abnormal enzyme activity and deregulated cell growth. "The mutated or overexpressed receptors tend to be associated with cancers of the brain, breast, ovary, prostate, and pancreas," explains lead author O'Rourke. "There are either more receptors on the cell than normal or the ones that are there are more active."

The researchers are aiming for a more targeted approach than radiation and chemotherapy to kill cancer cells that remain after surgery. "ErbBs are a natural target to block," says O'Rourke. "There's more of a biological likelihood that we may impact this disease and minimize side effects using this strategy."

The group is currently working on several ways to inactivate erbB receptor proteins. One is a form of gene therapy to make cancer cells express a non-active receptor. "The second form of inhibition, which is even more promising, will be the use of smaller compounds called peptide mimetics," says O'Rourke. "These compounds are less complicated and work directly on the cell surface, eliminating the need to get to the cell's nucleus, as with gene therapy." The team is currently designing human clinical trials, notes O'Rourke, but they're still about six to twelve months away from starting trials.


'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
(215) 614-0290
University of Pennsylvania School of Medicine
16-Sep-1998


Page: 1 2

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy dramatically improves function after spinal cord injury in rats
3. Combination therapy drives cancer into remission
4. Combination drug therapy drastically reduces multiple coronary heart disease risk factors
5. Combination therapy improves anthrax survival
6. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. 1st International Conference on Cell Therapy for Cardiovascular Disease
10. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
11. Braunschweig Prize 2003 for Molecular Cancer Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2020)... ... 2020 , ... With numerous products in its pipeline, Cytonus ... Cytonus’ existing products and to expand the companies’ intellectual property assets. Cytonus is ... located in Austria. , Phoenestra has developed IP assets in connection with ...
(Date:3/5/2020)... ... March 05, 2020 , ... Diagenode, a leading ... Tech (MGI), a subsidiary of global genomics leader BGI Group, today announced a ... States, Europe and Asia Pacific. , Under the terms of the non-exclusive ...
(Date:3/4/2020)... ... March 04, 2020 , ... The Massachusetts Medical Device Industry ... IGNITE program’s 2020 IGNITE Cohort. The MedTech IGNITE Program is a virtual accelerator ... next generation of medtech founders and entrepreneurs. IGNITE Cohort members get access to ...
Breaking Biology News(10 mins):
(Date:3/4/2020)... ... March 04, 2020 , ... This month, Cognosante will ... FL. The company will showcase both expanded and emerging offerings that align with the ... is designed to be comprehensive, timely, and engaging. From Interoperability and ...
(Date:2/28/2020)... ... February 26, 2020 , ... Designed primarily ... camera with a dedicated controller, thus simplifying setup, streamlining integration, and optimizing workflow. ... the first of Fastec Imaging’s new HS Series cameras to be released. The ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... chain transparency and reassuring consumers that what’s listed on an ingredient panel is ... Nutrition21 has introduced this solution with the adoption of CertainT, which is designed ...
(Date:2/19/2020)... (PRWEB) , ... February 18, 2020 , ... ... medical devices, today announced the launch of a new and unified global brand ... tackle the industry’s most complex engineering challenges, as well as an enthusiasm for ...
Breaking Biology Technology:
Cached News: