Combination drug therapy drastically reduces multiple coronary heart disease risk factors

DALLAS April 12, 2003 Combining two lipid-lowering medications safely and effectively reduces multiple coronary heart disease risk factors, according to UT Southwestern Medical Center at Dallas researchers.

The researchers combined a low dose of a medication that targets low-density lipoprotein (LDL) cholesterol, or the bad cholesterol, with a second drug therapy that increases high-density lipoprotein (HDL), the good cholesterol. The study involved 20 patients with combined hyperlipidemia, which is primarily characterized by high triglycerides, high LDL cholesterol and low HDL cholesterol.

The study, reported in the April 15 issue of the American Journal of Cardiology, found that a specific drug combination low-dose simvastatin (Zocor) and fenofibrate resulted in a 52 percent reduction in triglycerides, a 23 percent increase in HDL and a 28 percent reduction in LDL.

Drug treatment for combined hyperlipidemia presents a challenge because single drug therapy rarely corrects all of the lipoprotein abnormalities observed in this condition, said Dr. Gloria Vega, professor of clinical nutrition and the studys principal investigator. High LDL is a well-established risk factor for coronary heart disease, and high triglycerides and low HDL worsen the risk. Successful management of this condition may require combined drug therapy.

This study provides reasonable evidence that a low dose of a statin plus fenofibrate is a relatively safe and effective drug combination for treating LDL and several emerging risk factors for coronary heart disease. No significant side effects were observed with either the cholesterol-lowering drug alone or with co-administration of the statin and fenofibrate, said Vega.

Dr. Nilo Cater, assistant professor of internal medicine and co-author of the study, said, The rationale for looking into the combination is that there are not only people who have elevations in their LDL, but they also have abnormalities

Contact: Amy Shields
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy dramatically improves function after spinal cord injury in rats
3. Combination therapy drives cancer into remission
4. Combination therapy improves anthrax survival
5. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
6. Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. Targeted therapy knocks out pediatric brain cancer in mice
10. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
11. Columbia research to examine gene influence on severity of peridontal disease, therapy response

Post Your Comments:

(Date:4/5/2019)... ... April 04, 2019 , ... PI’s ... providing 0.05 microns and 0.005 microns resolution, respectively. The new design allows for ... available, from fast DC-servo motors with linear encoders and low-friction ball-screws to simple ...
(Date:4/4/2019)... ... 2019 , ... The live session taking place ... connectivity between product risk management (ISO 14971) and the clinical risk management process ... With increasing global regulation and reimbursement challenges faced by medical device companies, it ...
(Date:4/1/2019)... ... April 01, 2019 , ... uBiome announces ... Related Conditions” by the US Patent and Trademark Office on January 1, 2019 ... by uBiome collaborators Dr. Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, ...
Breaking Biology News(10 mins):
(Date:3/23/2019)... ... March 22, 2019 , ... Tosoh Bioscience LLC is proud ... , offering a revolutionary approach for the measurement of molecular weight (MW) and ... optical design, a unique cell-block assembly, and a new calculation methodology make the ...
(Date:3/19/2019)... ... March 19, 2019 , ... ... Minolta) today announced the formation of their inaugural Scientific Advisory Board. ... medicine that takes into account individual variability in genes, environment, and lifestyle to ...
(Date:3/18/2019)... SANTA BARBARA, Calif. (PRWEB) , ... March 18, 2019 , ... ... have partnered together to develop solutions that allow life science companies to easily ... regulatory requirements. USDM’s Cloud Assurance ™ is a managed service delivering end-to-end GxP ...
(Date:3/14/2019)... ROCK, Ark. (PRWEB) , ... March 14, 2019 ... ... America’s 29th Annual Conference & Expo, themed “Navigating the Full Spectrum of Case ... Vegas, NV, June 10-14, 2019. This conference is the only case management industry ...
Breaking Biology Technology:
Cached News: