Combination drug therapy drastically reduces multiple coronary heart disease risk factors

DALLAS April 12, 2003 Combining two lipid-lowering medications safely and effectively reduces multiple coronary heart disease risk factors, according to UT Southwestern Medical Center at Dallas researchers.

The researchers combined a low dose of a medication that targets low-density lipoprotein (LDL) cholesterol, or the bad cholesterol, with a second drug therapy that increases high-density lipoprotein (HDL), the good cholesterol. The study involved 20 patients with combined hyperlipidemia, which is primarily characterized by high triglycerides, high LDL cholesterol and low HDL cholesterol.

The study, reported in the April 15 issue of the American Journal of Cardiology, found that a specific drug combination low-dose simvastatin (Zocor) and fenofibrate resulted in a 52 percent reduction in triglycerides, a 23 percent increase in HDL and a 28 percent reduction in LDL.

Drug treatment for combined hyperlipidemia presents a challenge because single drug therapy rarely corrects all of the lipoprotein abnormalities observed in this condition, said Dr. Gloria Vega, professor of clinical nutrition and the studys principal investigator. High LDL is a well-established risk factor for coronary heart disease, and high triglycerides and low HDL worsen the risk. Successful management of this condition may require combined drug therapy.

This study provides reasonable evidence that a low dose of a statin plus fenofibrate is a relatively safe and effective drug combination for treating LDL and several emerging risk factors for coronary heart disease. No significant side effects were observed with either the cholesterol-lowering drug alone or with co-administration of the statin and fenofibrate, said Vega.

Dr. Nilo Cater, assistant professor of internal medicine and co-author of the study, said, The rationale for looking into the combination is that there are not only people who have elevations in their LDL, but they also have abnormalities

Contact: Amy Shields
UT Southwestern Medical Center

Page: 1 2

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy dramatically improves function after spinal cord injury in rats
3. Combination therapy drives cancer into remission
4. Combination therapy improves anthrax survival
5. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
6. Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. Targeted therapy knocks out pediatric brain cancer in mice
10. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
11. Columbia research to examine gene influence on severity of peridontal disease, therapy response

Post Your Comments:

(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, the multi-platform endpoint management ... launch of version 13.1. The new version extends FileWave’s mobile device management features ... spring release functionality. Version 13.1 builds on FileWave’s version 13 that was released ...
(Date:5/31/2019)... ... 30, 2019 , ... Join Julie Peacock, Vice President of ... Wednesday, June 19, 2019 at 1pm EDT where she will demonstrate how role-based ... and contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. ...
(Date:5/31/2019)... ... May 31, 2019 , ... The OilComm Conference & ... announced today that Ben Reiter, Senior Writer at Sports Illustrated and Author of ... , Reiter predicted the Houston Astros would win the MLB championship in 2014 ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... BOSTON (PRWEB) , ... May 30, 2019 , ... ... Current regulatory thinking on Data Integrity on July 08-09, 2019 in Boston, MA. ... pharmaceutical, biotech and medical device organizations. , The training will kick off with ...
(Date:5/15/2019)... HERSHEY, Pa. (PRWEB) , ... May 15, 2019 , ... ... the Year in recognition for his work within the biomedical industry, where he is ... and improved medical devices. , “William Harding epitomizes the vision of our founders ...
(Date:5/7/2019)... British Columbia (PRWEB) , ... May 06, 2019 ... ... be a go-to resource for the growing number of repositories being asked to ... We are grateful to the team of contributors who are world leaders, who ...
(Date:5/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology ...
Breaking Biology Technology:
Cached News: