HOME >> BIOLOGY >> NEWS
Combination therapy dramatically improves function after spinal cord injury in rats

A combination therapy using transplanted cells plus two experimental drugs significantly improves function in paralyzed rats, a new study shows. The results suggest that a similar therapy may be useful in humans with spinal cord injury. The study was funded in part by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, and appears in the June 2004 issue of Nature Medicine.*

About 10,000 people in the United States suffer spinal cord injuries each year. Studies in animals during the past decade have shown that supporting cells from nerves outside the brain and spinal cord, called Schwann cells, can be used to make a "bridge" across the damaged spinal cord that encourages nerve fibers to regrow. Other research has suggested that a substance called cyclic AMP (cyclic adenosine monophosphate) can turn on growth factor genes in nerve cells, stimulating growth and helping to overcome signals that normally inhibit regeneration. This study is the first to try a combination of the two approaches in an animal model of spinal cord injury.

In the new study, Mary Bartlett Bunge, Ph.D., Damien Pearse, Ph.D., and colleagues at the Miami Project to Cure Paralysis at the University of Miami School of Medicine, found that spinal cord injury triggers a loss of cAMP in the spinal cord and in some parts of the brain. They then transplanted Schwann cells into the spinal cords of rats in a way that bridged the damaged area. The researchers also gave the rats a form of cAMP and a drug called rolipram, which prevents cAMP from being broken down.

Treatment with the triple-combination therapy preserved and even elevated cAMP levels in nerve cells after injury. It also preserved many of the myelinated nerve fibers in treated animals, compared to untreated rats and those that did not receive the triple combination, the researchers found. Myelin is a fatty substance that insulates the nerve fibers and
'"/>

Contact: Natalie Frazin or Paul Girolami
301-496-5924
NIH/National Institute of Neurological Disorders and Stroke
23-May-2004


Page: 1 2

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy drives cancer into remission
3. Combination drug therapy drastically reduces multiple coronary heart disease risk factors
4. Combination therapy improves anthrax survival
5. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
6. Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. Targeted therapy knocks out pediatric brain cancer in mice
10. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
11. Columbia research to examine gene influence on severity of peridontal disease, therapy response

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... N.J. (PRWEB) , ... February ... ... the leading global provider of advanced delivery technologies and development solutions for ... The Procter & Gamble Company’s (P&G) highest external business partner recognition, the ...
(Date:2/13/2019)... ... February 13, 2019 , ... ... Medication Distribution System. It features Wi-Fi enabled RFID Locks that provide healthcare facilities ... a live audit trail on the network for superior access control and shrinkage ...
(Date:2/11/2019)... (PRWEB) , ... February 11, 2019 , ... ... DNA analysis products and services, announced a new forensic genealogy service offering to ... combines advanced DNA testing and genealogy to develop ancestral relationships between samples ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... March 14, 2019 , ... EyeCRO LLC has ... OK. EyeCRO joins the Department of Veterans Affairs, the Oklahoma Medical Research Foundation, ... fifth institution in Oklahoma to receive this prestigious endorsement. The award letter ...
(Date:3/14/2019)... MURRIETA, Calif. (PRWEB) , ... March 13, 2019 , ... ... Advisory Board. The Board will bring industry specific and broader business experience to bear ... the incubator to have access to the knowledge and expertise that our Advisory Board ...
(Date:3/12/2019)... and LIÈGE, Belgium (PRWEB) , ... March 12, ... ... solutions for sample preparation and epigenetics research, has launched its third generation long-fragment ... of the second generation instrument with a user-friendly interface, automated processing, and ...
(Date:3/9/2019)... ... March 08, 2019 , ... ... education planning, announced the release of their Best Online Master's in Biotechnology ... based on curriculum quality, program flexibility, affordability, and graduate outcomes. , In ...
Breaking Biology Technology:
Cached News: