Combination therapy improves anthrax survival

BALTIMORE March 10, 2003 Treating anthrax patients with a combination of antibiotics and antibodies could greatly improve their likelihood of survival, say researchers today at the American Society for Microbiology's Biodefense Research Meeting.

"Currently there is no effective treatment for inhalation anthrax beyond administration of antibiotics shortly after exposure," says Vladimir Karginov of Advanced Biosystems, Inc. in Manassas, Virginia, a lead researcher in the study. "Time delay reduces the effectiveness of antibiotic treatment. There is need for new, safe and effective treatments to supplement traditional antibiotic therapy."

Antibiotic therapy for inhalation anthrax is generally only effective if it is started within days of exposure, before symptoms appear. By the time symptoms do appear antibiotics alone will not work because while they do kill the bacteria, anthrax toxin has already accumulated in the body to dangerous levels and the chances of dying are extremely high.

Karginov and his colleagues have developed a treatment strategy that addresses this problem. In addition to antibiotics to kill the infection, patients can also be given antibodies that programmed to attack a part of the toxin called the protective antigen and prevent it from doing damage.

"In animals infected with a dose of anthrax spores sufficient to cause 80 percent mortality, antibiotic treatment with ciprofloxacin alone only cures 50 percent of infected animals," says Karginov. "In contrast, administration of rabbit antibodies either against heat inactivated anthrax bacteria or against protective antigen in combination with ciprofloxacin produced 100 percent survival."


Contact: Jim Sliwa
American Society for Microbiology

Page: 1

Related biology news :

1. Combination of gene therapy and gene silencing prevents neurodegenerative disease
2. Combination therapy dramatically improves function after spinal cord injury in rats
3. Combination therapy drives cancer into remission
4. Combination drug therapy drastically reduces multiple coronary heart disease risk factors
5. Drug Combination May Prove Effective To Prevent Recurrence Of Hepatitis C After Transplantation
6. Combination Therapy For Brain Tumors Holds Promise For Longer Survival After Surgery
7. New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
8. Dangerous Chemical Combination Presents Possible Scenario For Gulf War Illnesses
9. Targeted therapy knocks out pediatric brain cancer in mice
10. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
11. Columbia research to examine gene influence on severity of peridontal disease, therapy response

Post Your Comments:

(Date:3/5/2020)... ... March 05, 2020 , ... ... technology . The AlphaSTEM Test™ is the first, and still only, available ... Other technologies that attempt to provide information about the number and quality of ...
(Date:3/4/2020)... ... 04, 2020 , ... VGXI, Inc., a uniquely specialized CDMO ... as a finalist in the category of Best Contract Manufacturing Organization for the ... of a DNA vaccine against the novel coronavirus, COVID-19, under a CEPI funded ...
(Date:3/3/2020)... , ... March 03, 2020 , ... Board-certified oral and ... ND. With over 16 years of training and experience, Dr. Noffze can successfully extract ... wisdom teeth as soon as possible is beneficial to the oral and overall health ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... February 21, 2020 , ... Join Forrest Brown, Engineering Services Manager – ... Inc. for an informative session on Wednesday, February 26, 2020 at ... to incorporate into facility design to add manufacturing flexibility in the future, especially for ...
(Date:2/19/2020)... ... 2020 , ... Intech , the leader in contract ... unified global brand identity, as it celebrates its 20th anniversary. , Fueled by ... an enthusiasm for designing and manufacturing state-of-the-art medical devices, Intech has grown leaps ...
(Date:2/11/2020)... BOSTON (PRWEB) , ... February ... ... privately-owned company) is pleased to announce the successful results from a long-term ... stenosis using the Inspan interspinous fixation device (INSPAN LLC). Unlike extension block ...
(Date:2/5/2020)... ... February 04, 2020 , ... Shoreline ... down to the strain level, has announced a new distribution partnership in Asia. ... and other products to companies and research organizations in China, Hong Kong, and ...
Breaking Biology Technology:
Cached News: