Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each

Adding low doses of angiostatin -- a naturally produced substance that inhibits the formation of new blood vessels -- to standard radiation therapy dramatically improves the response to cancer treatment in animal models without increasing toxicity, report researchers from the University of Chicago Medical Center, Harvard Medical School and Northwestern University in the July 16 issue of Nature.

Human angiostatin alone produced only a modest decrease in tumor growth when given to mice with large tumors. Radiation therapy alone produced a slightly greater response. The combination of angiostatin and radiation, however, caused significant growth inhibition, demonstrating a powerful synergistic effect, even in mice with very large tumors.

"Our finding suggests that radiation therapy, already a standard of cancer care, could be dramatically improved by simultaneous administration of relatively small doses of angiostatin," said Ralph Weichselbaum, M.D., professor and chairman of radiation oncology at the University of Chicago and director of the study. "This combination could make radiation much more effective at providing local control of cancer, a crucial part of treatment for many tumors, including prostate, brain, head and neck and other cancers. It could even expand the use of radiation therapy to some forms of metastatic disease without requiring high doses."

The researchers also studied the combination of radiation plus mouse angiostatin against human cancers of the brain, head and neck, and prostate that had been transplanted into mice. Once again, the combination was far more effective than the combined effects of each therapy used alone.

For example, in mice with large radiation-resistant human tumors (SQ20-B, a form of head and neck cancer), angiostatin alone reduced the tumor volume 16 percent, radiation alone reduced volume 18 percent, but combined therapy reduced the average tumor volume 64 percent.

Surprisingly, tumors treated

Contact: John Easton
773 702 6241
University of Chicago Medical Center

Page: 1 2 3

Related biology news :

1. Combining various magnetic resonance imaging techniques may help improve breast cancer detection
2. Combining global environmental changes yields surprising ecosystem response
3. Combining key ingredients of vegetarian diet cuts cholesterol significantly, says study
4. Combining Rb2 gene with radiation therapy quickens tumor cell death, Temple researchers find
5. Combining medical, agricultural and chemical research, UF Genetics Institute is making an impact and attracting renowned scientists
6. Dazzling new light source opens at Stanford Synchrotron Radiation Laboratory
7. Radiation therapy targets cancer cells on two fronts, Science study says
8. Radiation-resistant organism reveals its defense strategies
9. Radiation alone after surgery still the standard for head and neck cancer
10. Stanford Synchrotron Radiation Lab receives $6 million grant to decipher protein structures
11. No More Running Blind In A Maze-The Laboratory Rat Genetic And Radiation Hybrid Map Is Here

Post Your Comments:

(Date:11/27/2019)... ... November 26, 2019 , ... Smile Glen Ellyn dentists, Drs. ... Invisalign® treatment. Invisalign orthodontics uses a series of clear, virtually invisible ... known as malocclusion, present both functional and cosmetic concerns. Functionally, crooked teeth ...
(Date:11/27/2019)... ... November 27, 2019 , ... ... hand-held device, equipped with surface electromyography (sEMG) sensors that measure and display muscle ... of the specific muscles being targeted for treatment. Both patient and therapist can ...
(Date:11/20/2019)... ... November 20, 2019 , ... BioInformatics Inc., part of Science and Medicine ... announced the winners of the Life Science Industry Awards for the most innovative new ... Awards – Innovation: , Most Innovative New Product – Cell Biology, ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... ... ... German Shepherd, was demonstrating signs of osteoarthritis in April 2019. He was lame and ... willingness to play were normal, it was clear that he was in pain. , Ole’s ... and Referral Center in San Diego, California. Dr. Mullen is an experienced VetStem ...
(Date:11/2/2019)... NEW YORK (PRWEB) , ... October 31, 2019 ... ... just been released by pharma artificial intelligence pioneer tellic. drug360 brings tellic’s ... data. This new tool allows researchers to quickly uncover relationships between genes, diseases, ...
(Date:10/29/2019)... ... ... CaroGen Corporation , a biotechnology company, today announced three distinguished additions to ... MD, of Brown University , Dr. Steve Projan, PhD, FAAM, formerly of ... Wayne State University, formerly a professor at Yale University School of Medicine ...
(Date:10/26/2019)... ... , ... Sparks Marketing Group, Inc. (Sparks) announced ... healthcare-specific marketing firm, to strengthen the agency’s growing focus on the healthcare vertical ... in pharma, bio-therapeutics, medical device and healthcare technologies currently account for a large ...
Breaking Biology Technology:
Cached News: