HOME >> BIOLOGY >> NEWS
Combining Rb2 gene with radiation therapy quickens tumor cell death, Temple researchers find

Combining the tumor suppressing Rb2 gene with doses of gamma radiation speeds up the ability of tumor cells to die, according to a study by researchers at Temple University's College of Science and Technology.

The results of the study, "pRb2/p130 promotes radiation-induced death in glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation," appear in the August 29 issue of Oncogene (Vol. 21, Issue 38).

In the study, which was started at Thomas Jefferson University and completed at Temple's Sbarro Institute for Cancer Research and Molecular Medicine, the researchers found that when they treated tumor cells in which the Rb2 gene has been transplanted with gamma radiation, there was an increase of almost 50 percent in the ability of the cells to destroy themselves.

"One of the characteristics of the tumor cells is, at a certain point, the ability of the cell to program its own death, which is called apoptosis," says Antonio Giordano, Ph.D., M.D., head of the Sbarro Institute and one of the study's lead researchers. "In this case, we wanted to know if the introduction of the Rb2 gene into the tumor cell was creating apoptosis."

Giordano says that in order to kill tumor cells through apoptosis, the cells can be treated with gamma radiation, but that this therapy doesn't always have the desired effect.

In their study, the researchers transplanted a correct copy of the Rb2 into an aggressive brain tumor known as a glioblastoma using a vector that is sensitive to the drug tetracycline.

"When you have the presence of tetracycline, the Rb2 gene is in a silent state," says Giordano. "When you remove the tetracycline, you enhance the Rb2 gene expression and the tumor cells die.'

As part of the study, the researchers treated the tumor cells in which they had transplanted the Rb2 gene with gamma radiation. "When we looked at the possible synergistic role between gamma radiation and the Rb2 gene therapy, we saw that
'"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-7476
Temple University
26-Aug-2002


Page: 1 2

Related biology news :

1. Combining various magnetic resonance imaging techniques may help improve breast cancer detection
2. Combining global environmental changes yields surprising ecosystem response
3. Combining key ingredients of vegetarian diet cuts cholesterol significantly, says study
4. Combining medical, agricultural and chemical research, UF Genetics Institute is making an impact and attracting renowned scientists
5. Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each
6. New evidence of radiation risk in childhood leukaemia
7. Chernobyl study: Risk of thyroid cancer rises with radiation dose
8. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
9. New insight into how tumors resist radiation
10. Ultraviolet irradiation in ventilation systems could reduce office sickness
11. Diet may improve cognition, slow aging, and help protect against cosmic radiation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2017)... 1, 2017  Central to its deep commitment ... worldwide, The Japan Prize Foundation today announced the ... pushed the envelope in their respective fields of ... scientists are being recognized with the 2017 Japan ... only contribute to the advancement of science and ...
(Date:1/30/2017)...   Invitae Corporation (NYSE: NVTA ... today announced that it will report its fourth quarter ... on Monday, February 13, 2017, and Invitae,s management team ... p.m. Eastern / 1:45 p.m. Pacific. ... financial results, guidance, and recent developments and will spend ...
(Date:1/25/2017)... YORK , Jan. 25, 2017 The ... Access Management (IAM) lifecycle is comprised of a ... for the purpose of maintaining digital identities and ... resources and applications. There are significant number of ... from time to time by optimizing processes and ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... ... February 23, 2017 , ... Brain Sentinel, Inc. has received ... SPEAC® System, the Brain Sentinel® Seizure Monitoring and Alerting System. The adjunctive seizure ... periods of rest. A lightweight, non-invasive monitor is placed on the belly of ...
(Date:2/23/2017)... ... , ... The Greater Gift Initiative, Inc , (GGI) a Winston-Salem, NC ... GGI's mission is to advance global health and highlight the greater good of clinical ... each clinical trial volunteer. The vision of GGI is to serve as a philanthropic ...
(Date:2/23/2017)... ... February 22, 2017 , ... ... , have been named Fellows of the Society this year, the Fellows Committee ... the multidisciplinary fields of optics, photonics, and imaging as well as their service ...
(Date:2/22/2017)...  PrimeVax Immuno-Oncology, Inc. announced today its CEO, ... Biocom Global Life Science Partnering Conference.  The presentation will ... the Torrey Pines Lodge, in San Diego.  ... who have chosen our company, amongst numerous others, to ... and clinical researchers," said Mr. Chen. "In contrast to ...
Breaking Biology Technology:
Cached News: