HOME >> BIOLOGY >> NEWS
Combining Rb2 gene with radiation therapy quickens tumor cell death, Temple researchers find

Combining the tumor suppressing Rb2 gene with doses of gamma radiation speeds up the ability of tumor cells to die, according to a study by researchers at Temple University's College of Science and Technology.

The results of the study, "pRb2/p130 promotes radiation-induced death in glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation," appear in the August 29 issue of Oncogene (Vol. 21, Issue 38).

In the study, which was started at Thomas Jefferson University and completed at Temple's Sbarro Institute for Cancer Research and Molecular Medicine, the researchers found that when they treated tumor cells in which the Rb2 gene has been transplanted with gamma radiation, there was an increase of almost 50 percent in the ability of the cells to destroy themselves.

"One of the characteristics of the tumor cells is, at a certain point, the ability of the cell to program its own death, which is called apoptosis," says Antonio Giordano, Ph.D., M.D., head of the Sbarro Institute and one of the study's lead researchers. "In this case, we wanted to know if the introduction of the Rb2 gene into the tumor cell was creating apoptosis."

Giordano says that in order to kill tumor cells through apoptosis, the cells can be treated with gamma radiation, but that this therapy doesn't always have the desired effect.

In their study, the researchers transplanted a correct copy of the Rb2 into an aggressive brain tumor known as a glioblastoma using a vector that is sensitive to the drug tetracycline.

"When you have the presence of tetracycline, the Rb2 gene is in a silent state," says Giordano. "When you remove the tetracycline, you enhance the Rb2 gene expression and the tumor cells die.'

As part of the study, the researchers treated the tumor cells in which they had transplanted the Rb2 gene with gamma radiation. "When we looked at the possible synergistic role between gamma radiation and the Rb2 gene therapy, we saw that
'"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-7476
Temple University
26-Aug-2002


Page: 1 2

Related biology news :

1. Combining various magnetic resonance imaging techniques may help improve breast cancer detection
2. Combining global environmental changes yields surprising ecosystem response
3. Combining key ingredients of vegetarian diet cuts cholesterol significantly, says study
4. Combining medical, agricultural and chemical research, UF Genetics Institute is making an impact and attracting renowned scientists
5. Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each
6. New evidence of radiation risk in childhood leukaemia
7. Chernobyl study: Risk of thyroid cancer rises with radiation dose
8. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
9. New insight into how tumors resist radiation
10. Ultraviolet irradiation in ventilation systems could reduce office sickness
11. Diet may improve cognition, slow aging, and help protect against cosmic radiation

Post Your Comments:
(Date:4/17/2014)... . Our eyes ... us with a continuous stream of information about our own ... in a car the world glides by us and ... effort, our brain calculates self-motion from this "optic flow". This ... gaze during our own movements. Together with biologists from the ...
(Date:4/17/2014)... years ago, Katia Silvera , a postdoctoral scholar at ... a field trip in a mountainous area in central Panama ... before. , Unable to identify it, they contacted German Carnevali, ... to be an unnamed species. So Carnevali recently named it ... the genus name, comprising about 40 species in the world. ...
(Date:4/17/2014)... in Europe, Asia and the United States are spreading ... impacting native honeybee populations at this time, according to ... including Nosema microsporidia and Varroa ... to these invasive pests, which suggests to us that ... and the United States currently are not necessary in ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
(Date:1/14/2014)... 14, 2014 Date: Friday, April 11, 2014 ... Country Club, 1360 Almshouse Road, Warrington, Pa. , ... solely dedicated to finding a cure for hepatitis B and ... host its annual Crystal Ball on Friday, April 11 at ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
Cached News: