HOME >> BIOLOGY >> NEWS
Combining Rb2 gene with radiation therapy quickens tumor cell death, Temple researchers find

Combining the tumor suppressing Rb2 gene with doses of gamma radiation speeds up the ability of tumor cells to die, according to a study by researchers at Temple University's College of Science and Technology.

The results of the study, "pRb2/p130 promotes radiation-induced death in glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation," appear in the August 29 issue of Oncogene (Vol. 21, Issue 38).

In the study, which was started at Thomas Jefferson University and completed at Temple's Sbarro Institute for Cancer Research and Molecular Medicine, the researchers found that when they treated tumor cells in which the Rb2 gene has been transplanted with gamma radiation, there was an increase of almost 50 percent in the ability of the cells to destroy themselves.

"One of the characteristics of the tumor cells is, at a certain point, the ability of the cell to program its own death, which is called apoptosis," says Antonio Giordano, Ph.D., M.D., head of the Sbarro Institute and one of the study's lead researchers. "In this case, we wanted to know if the introduction of the Rb2 gene into the tumor cell was creating apoptosis."

Giordano says that in order to kill tumor cells through apoptosis, the cells can be treated with gamma radiation, but that this therapy doesn't always have the desired effect.

In their study, the researchers transplanted a correct copy of the Rb2 into an aggressive brain tumor known as a glioblastoma using a vector that is sensitive to the drug tetracycline.

"When you have the presence of tetracycline, the Rb2 gene is in a silent state," says Giordano. "When you remove the tetracycline, you enhance the Rb2 gene expression and the tumor cells die.'

As part of the study, the researchers treated the tumor cells in which they had transplanted the Rb2 gene with gamma radiation. "When we looked at the possible synergistic role between gamma radiation and the Rb2 gene therapy, we saw that
'"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-7476
Temple University
26-Aug-2002


Page: 1 2

Related biology news :

1. Combining various magnetic resonance imaging techniques may help improve breast cancer detection
2. Combining global environmental changes yields surprising ecosystem response
3. Combining key ingredients of vegetarian diet cuts cholesterol significantly, says study
4. Combining medical, agricultural and chemical research, UF Genetics Institute is making an impact and attracting renowned scientists
5. Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each
6. New evidence of radiation risk in childhood leukaemia
7. Chernobyl study: Risk of thyroid cancer rises with radiation dose
8. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
9. New insight into how tumors resist radiation
10. Ultraviolet irradiation in ventilation systems could reduce office sickness
11. Diet may improve cognition, slow aging, and help protect against cosmic radiation

Post Your Comments:
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a ... announced that its DigitalPersona ® Pro Enterprise ... have been deployed throughout First Bank branch locations ... South Carolina and Virginia. First Bank, ... Southern Pines, North Carolina , selected ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
(Date:11/18/2014)... WASHINGTON , Nov. 18, 2014  The ... Security Industry Association today jointly announce the formation ... and release of its Identity and Biometric ... (Framework). The Framework received official support from BORDERPOL, ... governments to improve and provide expertise regarding border ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
(Date:12/19/2014)... FL (PRWEB) December 18, 2014 ... the nation’s leading specialty pharmacies, has an expanded ... as clinical pharmacy consultants for prescriber offices in ... expertise. , “We have a variety of ... For example, those specializing in hepatitis C help ...
(Date:12/19/2014)... LayerBio is an MIT spin-off developing ... The National Eye Institute (NEI) at the National Institutes ... SBIR grant to develop a drug-eluting intraocular lens (IOL) ... cause of vision loss in people over age 40 ... Dr. Ken Mandell, LayerBio’s Founder and CEO, "There is ...
(Date:12/19/2014)... 2014 Reports from CDC ... suffer from one or more chronic health conditions - ... can address some of these diseases, but may not ... sufferers face. While implanted nerve stimulation devices today offer ... nerve, which can induce side effects. , To ...
(Date:12/19/2014)... In contrast to traditional LED lights where the ... uses proprietary LED technology to incorporate their spectra in ... is critical in low proximity installations. The Valoya L-series ... lifetime which is up to four times longer than ... cost was clearly higher when compared to traditional fluorescent ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2
Cached News: