Common enzyme deficiency may jeopardize p...( ction of red blood cells in adults expo...)

Common enzyme deficiency may jeopardize pregnancies

ction of red blood cells in adults exposed to oxidant drugs like antimalerial agents. There have been no investigations of the impact of the hereditary condition on developing embryos.

"This is an enzyme that's been around forever and people have always thought it was of only limited toxicological interest," says Wells. "Presumably these new findings will now stimulate people to start looking carefully at mothers with the hereditary enzyme deficiency to see whether, for example, it takes longer for them to get pregnant -- because they may be unknowingly conceiving and then losing their babies very early on -- or they have more miscarriages or have more children with birth defects."

Screening for G6PD deficiency is a simple process, Wells says, and if studies show it causes similar problems in human pregnancy then potential antioxidant therapies could be evaluated for their safety in pregnant women.

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Contact: Megan Easton
megan.easton@utoronto.ca
416-978-5948
University of Toronto
2-Jan-2000

Page: 1 2
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