HOME >> BIOLOGY >> NEWS
Common nutrients fed to pregnant mice altered their offspring's coat color

called "DNA methylation" -- could potentially affect dozens of other genes that make humans and animals susceptible to cancer, obesity, diabetes, and even autism, he said.

"Our study demonstrates how early environmental factors can alter gene expression without mutating the gene itself," said Rob Waterland, Ph.D., a research fellow in the Jirtle laboratory and lead author of the study. "The implications for humans are huge because methylation is a common event in the human genome, and it is clearly a malleable effect that is subject to subtle changes in utero."

During DNA methylation, a quartet of atoms -- called a methyl group attaches to a gene at a specific point and alters its function. Methylation leaves the gene itself unchanged. Instead, the methyl group conveys a message to silence the gene or reduce its expression inside a given cell. Such an effect is referred to as "epigenetic" because it occurs over and above the gene sequence without altering any of the letters of the four-unit genetic code.

In the treated mice, one or several of the four nutrients caused the Agouti gene to become methylated, thereby reducing its expression and potentially that of other genes, as well. Moreover, the methylation occurred early during gestation, as evidenced by its widespread manifestation throughout cells in the liver, brain, kidney and tail.

"Our data suggest these changes occur early in embryonic development, before one would even be aware of the pregnancy," said Jirtle. "Any environmental condition that impacts these windows in early development can result in developmental changes that are life-long, some of them beneficial and others detrimental."

If such epigenetic alterations occur in the developing sperm or eggs, they could even be passed on to the next generation, potentially becoming a permanent change in the family line, added Jirtle. In fact, data gathered by Swedish researcher Gunnar Kaati and colleagues indicates ju
'"/>

Contact: Becky Levine
levin005@mc.duke.edu
919-684-4148
Duke University Medical Center
1-Aug-2003


Page: 1 2 3 4

Related biology news :

1. Common cold virus can cause polio in mice when injected into muscles
2. Common call for action on European Research Council (ERC)
3. Common therapy for HIV associated with cervical abnormality regression
4. Common chemicals morphing into potential toxins in Arctic
5. Common worm provides insights into salmonella virulence
6. Common virus may contribute to uncommon bone disease in children
7. Common airborne substance makes asthmatics more sensitive to house dust mites: study
8. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
9. Common treatment for depression is safe and effective for Alzheimers patients
10. Common gene variant increases risk of atherosclerosis
11. Common thyroid cancer gene mutation found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/22/2020)... ... July 21, 2020 , ... ... innovation in technology and compliance, announces a new solution to manage regulated workloads ... every layer of their technology stack complies with FDA and global regulations. USDM's ...
(Date:7/10/2020)... CHICAGO (PRWEB) , ... July 09, 2020 , ... Today ... Umami Advantage, which will share insight on the “fifth taste” phenomenon that is revolutionizing ... snacks. The Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 12, 2020 , ... ... (EMMA International), a global leader in FDA compliance consulting has been named ... fastest-growing private companies. The list represents a unique look at the most successful ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... Corrigan, President and CEO has been named one of the 100 most inspiring ... sectors, PharmaVoice 100 honorees are selected based on how they have inspired their ...
(Date:7/31/2020)... SCOTTSDALE, Ariz. (PRWEB) , ... July 29, 2020 , ... ... cell joint injections for only $3950. With 50 million stem cells total, patients may ... well stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: