HOME >> BIOLOGY >> NEWS
Common therapy for HIV associated with cervical abnormality regression

Among women infected with human immunodeficiency virus (HIV), a combination of antiretroviral drugs that helps boost the immune system is associated with the regression of a type of cervical abnormality that can eventually lead to cancer, according to a study in the July 21 issue of the Journal of the National Cancer Institute.

HIV infection is associated with an increased risk of abnormalities in the cervix called squamous intraepithelial lesions (SIL). In healthy women, the low-grade form of this type of abnormality often disappears on its own without treatment. Also, women who are HIV-positive are at an increased risk of infection with human papillomavirus (HPV), which are known to cause cervical cancer and its precursor lesions.

Highly active antiretroviral therapy (HAART) is a combination of several antiretroviral drugs that reduces the number of HIV particles in the bloodstream and helps boost immune system function. However, it is unclear whether the boost in immune status afforded by HAART improves the regression rates of SIL.

Linda Ahdieh-Grant, Ph.D., of Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues analyzed data from the Women's Interagency HIV Study to examine the long-term effects of HAART on the regression of cervical SIL. Of the approximately 2,000 women who participated in the study, there were 312 women who had normal Pap smears at the time they entered the study and then, at some point during the 7 years of follow-up, were diagnosed with SIL.

The introduction of HAART was associated with a regression of SIL. Compared with women whose abnormality regressed, women whose lesions did not regress had more advanced HIV disease, including lower T-cell counts. Before women started HAART, the rate of disease regression was 0.0%; after HAART was introduced, the regression rate was 12.5%. However, the authors point out that the majority of the lesions in HIV-infected women, even among th
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
20-Jul-2004


Page: 1 2

Related biology news :

1. Common cold virus can cause polio in mice when injected into muscles
2. Common call for action on European Research Council (ERC)
3. Common chemicals morphing into potential toxins in Arctic
4. Common worm provides insights into salmonella virulence
5. Common virus may contribute to uncommon bone disease in children
6. Common airborne substance makes asthmatics more sensitive to house dust mites: study
7. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
8. Common nutrients fed to pregnant mice altered their offsprings coat color
9. Common treatment for depression is safe and effective for Alzheimers patients
10. Common gene variant increases risk of atherosclerosis
11. Common thyroid cancer gene mutation found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2019)... ... 2019 , ... Concerto HealthAI, a technology leader in definitive ... and other key therapeutic areas, and its Chief Executive Officer, Dr. Jeff Elton, ... the entire healthcare landscape, on January 8, 2019, at 2:30 p.m. in San ...
(Date:1/4/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars, or click below to learn more about each webinar: , CLINICAL ...
(Date:12/20/2018)... ... December 20, 2018 , ... Human Factors and ... of a new usability/observation room. This addition will help meet the increased industry ... drug delivery devices/combination products are safe and easy to use when released to ...
Breaking Biology News(10 mins):
(Date:12/18/2018)... (PRWEB) , ... December 17, 2018 , ... ... today the second cohort of emerging biosciences ventures invited to participate in the ... education to develop fundable business plans and a professional network. All startups receive ...
(Date:12/13/2018)... Md. (PRWEB) , ... December 12, 2018 , ... ... and other life science software solutions, announces the Limfinity® ML (Machine Learning) addition ... integrate trained machine learning models within Limfinity® solutions. In the module, trained models ...
(Date:12/5/2018)... ... 05, 2018 , ... The incredible life story of former refugee and LG ... by Carlos Moedas, the European Commissioner for Research and Innovation. , In his ... Lives, Commissioner Moedas spoke at length of Yousef’s life and journey, citing the man ...
(Date:11/27/2018)... ... 27, 2018 , ... New patients in need of a dental crown ... with or without a referral. Dr. Myers has many years of experience improving patient ... bridges and custom crowns. , As a dedicated cosmetic dentist , Dr. ...
Breaking Biology Technology:
Cached News: