HOME >> BIOLOGY >> NEWS
Common thyroid cancer gene mutation found

Researchers at the Johns Hopkins Kimmel Cancer Center have found that a single genetic mistake causes about two-thirds of papillary thyroid cancers. Their research, published in the April 16, 2003 issue of the Journal of the National Cancer Institute, may lead to new therapies that could counteract the mistake.

Hopkins researchers found a mutation of the BRAF (pronounced b-raf) gene in 68 percent (24 of 35 samples) of papillary thyroid cancers. These tumors account for about 75 percent of all thyroid cancer and occur mostly in women. "Until now, there have been no other major genetic events identified for common thyroid cancers," says David Sidransky, M.D., professor of otolaryngology and oncology at Johns Hopkins. "Our goal is to find better diagnostics and drug therapies designed to target the effects of this mutation."

The mistake involves a subtle change in the chemical bases (adenine, thymine, cytosine, and guanine) that make up DNA. The order in which these bases-or nucleotides-occur determines the information genes communicate to cells much like specific letters of the alphabet combine to form words and sentences. In the case of BRAF, the nucleotides are altered, and T (thymine) is switched to an A (adenine). The researchers found that this single coding error among more than 2000 nucleotides in the gene causes it to be stuck in the "on" position making thyroid cells continuously grow and divide, ultimately into cancer.

"Though most thyroid cancers can be cured by surgery and radioactive iodine treatments, it remains difficult to distinguish benign thyroid disease from cancer," says Sidransky. "Improvements in diagnostic tests and treatments using what we know about the BRAF mutation could speed up diagnosis and help patients survive advanced disease." Clinical trials for patients with papillary thyroid cancer who have not responded to surgery and radioactive iodine therapy are being planned.

Hopkins researchers also s
'"/>

Contact: Valerie Matthews Mehl
mehlva@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
15-Apr-2003


Page: 1 2

Related biology news :

1. Common cold virus can cause polio in mice when injected into muscles
2. Common call for action on European Research Council (ERC)
3. Common therapy for HIV associated with cervical abnormality regression
4. Common chemicals morphing into potential toxins in Arctic
5. Common worm provides insights into salmonella virulence
6. Common virus may contribute to uncommon bone disease in children
7. Common airborne substance makes asthmatics more sensitive to house dust mites: study
8. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
9. Common nutrients fed to pregnant mice altered their offsprings coat color
10. Common treatment for depression is safe and effective for Alzheimers patients
11. Common gene variant increases risk of atherosclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2020)... , ... February 04, 2020 , ... ... Office (USPTO) issued the company a second patent related to proprietary liquid crystal ... Allowance compliments another patent from the USPTO issued on December 3, 2019. Together, ...
(Date:1/29/2020)... ... January 29, 2020 , ... ... new Analytics and Data Sciences practice, providing consulting services for strategy, research and ... announced by Mike Townley, co-founder and Managing Partner of CREO, an innovative management ...
(Date:1/28/2020)... ... January 28, 2020 , ... ... care efficiency, reduce total cost of care, and limit the utilization of high-cost ... provider group headquartered in San Antonio, Texas specializes in improving care delivery for ...
Breaking Biology News(10 mins):
(Date:1/7/2020)... ... January 07, 2020 , ... ... services, today announced the launch of its VivopureX™ recombinant mouse antibodies for in ... originally obtained from rats or hamsters, which Absolute Antibody has engineered into mouse-anti-mouse ...
(Date:1/7/2020)... and SOMERVILLE, Mass. (PRWEB) , ... January 06, ... ... Murrow Center for a Digital World at The Fletcher School at Tufts University, ... Alfred P. Sloan Foundation. The grant will be administered by Tufts University, and ...
(Date:1/7/2020)... ... January 06, 2020 , ... ABCT , the Accelerator ... invited to participate in the annual program. Twelve ventures will participate in the ... professional network. All startups will receive an entrepreneur coach, access to active business ...
(Date:12/31/2019)... ... December 31, 2019 , ... At this year's SLAS conference, Visikol ... broadly focused on 3D cell culture , advanced imaging and ... assays for assessing steatosis , inflammation and fibrosis as well as ...
Breaking Biology Technology:
Cached News: