Common variation of 'klotho' gene associated with human life expectancy

"Klotho," a gene named for the Greek Fate purported to spin the thread of life, contributes to life expectancy in humans, according to a team led by Johns Hopkins scientists who report their findings in the Jan. 15 online version of the Proceedings of the National Academy of Sciences.

Studying more than 2,000 anonymous samples from three ethnically distinct groups of people, the scientists found that having two copies of a less-common version of klotho is twice as prevalent in infants as in people over age 65. These results suggest that people born with the two copies die sooner than others, although the gene's exact influence on health and aging are not known, the scientists say.

"The less-common klotho variant has a clear association with life expectancy in the groups we studied," says Hal Dietz, Ph.D., a Howard Hughes Medical Institute investigator and a member of the McKusick-Nathans Institute of Genetic Medicine at Hopkins. "As with all association studies, our work must now be validated by other scientists studying other populations, and the specific role of klotho in health and disease needs to be determined."

Previously, Japanese scientists discovered klotho in mice, noticing that without klotho's protein, the mice developed atherosclerosis, osteoporosis, emphysema and other conditions common in elderly humans. Because of their interest in accelerated aging diseases, Dietz and his colleagues began studying klotho in people.

They initially examined klotho in 611 infants and 435 elderly (over age 75) Bohemian Czechs, a fairly homogenous group of Central Europeans, then expanded their investigation to include the Women's Health and Aging Study (723 Caucasians and 242 African-Americans over the age of 65 in the Baltimore area) and 646 newborns in the Baltimore-Washington Infant Study.

In these groups, the scientists discovered a variant of klotho that has six changes in the gene sequence, two of which alter the prote

Contact: Joanna Downer
Johns Hopkins Medical Institutions

Page: 1 2 3

Related biology news :

1. Common cold virus can cause polio in mice when injected into muscles
2. Common call for action on European Research Council (ERC)
3. Common therapy for HIV associated with cervical abnormality regression
4. Common chemicals morphing into potential toxins in Arctic
5. Common worm provides insights into salmonella virulence
6. Common virus may contribute to uncommon bone disease in children
7. Common airborne substance makes asthmatics more sensitive to house dust mites: study
8. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
9. Common nutrients fed to pregnant mice altered their offsprings coat color
10. Common treatment for depression is safe and effective for Alzheimers patients
11. Common gene variant increases risk of atherosclerosis

Post Your Comments:

(Date:6/11/2020)... ... June 08, 2020 , ... ... and other protective measures to protect workers in the medical field. The face ... staffs who valiantly risk their lives every day to provide healthcare to pregnant ...
(Date:6/5/2020)... ... 04, 2020 , ... Murrieta Genomics has announced that its wholly ... sample preparation for Next Generation Genomic Sequencing (NGS) . This is the third ... of sample preparation. , “I have been at the bench for over 20 years,” ...
(Date:6/5/2020)... ... June 04, 2020 , ... Greffex, a pioneering vaccine and gene therapy company ... “Neil understands the need for a global perspective to make an impact in a ... Bush will serve as an independent, director of the company. , “The Greffex board ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... ... today announced that it has filed an Investigational New Drug application (IND) with ... trial of its lead drug candidate NBTX-001 in patients with panic disorder (PD). ...
(Date:6/11/2020)... ... 09, 2020 , ... PathSensors Inc., a Baltimore biotechnology company, ... (SBIR) program funded by the National Institute of Food and Agriculture (NIFA) entitled ... project’s goal was to engineer and develop a field-deployable instrument for portable pathogen ...
(Date:6/3/2020)... ... June 03, 2020 , ... ... various applications of biofeedback. In the next installment, Dr. Inna Khazan will discuss ... individuals learn to bring their attention to the feelings, thoughts, and emotions they ...
(Date:5/30/2020)... ... May 29, 2020 , ... The Conference ... first newsletter solely dedicated to the unique role of the Chief Medical Officer ... on the responsibilities, problem-solving, best practices and career development of CMOs and Heads ...
Breaking Biology Technology:
Cached News: