HOME >> BIOLOGY >> NEWS
Common virus may contribute to uncommon bone disease in children

A common virus may play a major role in causing a painful disease of immune cells that attacks children's bones, according to a new study. The research may eventually lead to an easier diagnosis and to more effective treatments of the disease, Langerhans cell histiocytosis.

Researchers found evidence of the virus, human herpesvirus 6 (HHV-6) in the tissues of 25 of 35 children with Langerhans cell histiocytosis (LCH), compared to virus detected in only five of 19 children without LCH. The research team, led by John P. Dormans, M.D., director of Orthopaedic Surgery at The Children's Hospital of Philadelphia, published its findings in the January/February issue of the Journal of Pediatric Orthopaedics.

Langerhans cells, found in the blood, play an active role in the immune system. An uncontrolled excess of Langerhans cells leads to LCH, with effects that range from a limited, spontaneously resolving illness to a chronic, life-threatening disease involving multiple organ systems. Although rare, occurring in approximately five children per million, LCH most commonly strikes bone, causing painful lesions or fractures.

"LCH is called the 'great imitator' because it resembles particular bone cancers," said Dr. Dormans. "Fortunately, most children survive the disease these days." Most bone lesions resolve on their own without treatment. In other cases, surgeons successfully treat the disease by removing the abnormal area of bone.

However, successful treatment may elude physicians when LCH is chronic and affects multiple systems. Chemotherapy may succeed, at least temporarily, but only for 50 to 60 percent of patients. The cause of LCH remains unknown, and the Children's Hospital researchers investigated its origins, with the goal of advancing treatments.

"It's important to define whether LCH is primarily a tumor-like process or a reactive process, that is, one in which the immune system reacts to an infection or other insult," said M
'"/>

Contact: Joey Marie McCool
McCool@email.chop.edu
267-426-6070
Children's Hospital of Philadelphia
8-Mar-2004


Page: 1 2

Related biology news :

1. Common cold virus can cause polio in mice when injected into muscles
2. Common call for action on European Research Council (ERC)
3. Common therapy for HIV associated with cervical abnormality regression
4. Common chemicals morphing into potential toxins in Arctic
5. Common worm provides insights into salmonella virulence
6. Common airborne substance makes asthmatics more sensitive to house dust mites: study
7. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
8. Common nutrients fed to pregnant mice altered their offsprings coat color
9. Common treatment for depression is safe and effective for Alzheimers patients
10. Common gene variant increases risk of atherosclerosis
11. Common thyroid cancer gene mutation found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... ... The ASGCT Clinical Trials Finder is a customizable search engine ... Data curated daily from ClinicalTrials.gov ensures the most up-to-date and applicable listings anywhere in ... in the development of the ASGCT Clinical Trials Finder reviewed the relevance ...
(Date:5/16/2019)... BOSTON (PRWEB) , ... May 16, 2019 , ... In ... Standards and Technology in Rockville, Maryland, March 18-19 of this year, Asymmetrex ... on the feasibility of standards for counting therapeutic adult tissue stem cells. Many ...
(Date:5/14/2019)... Md. (PRWEB) , ... May 14, 2019 , ... ... an expansion of their business strategy beyond immuno-oncology into areas of autoimmunity, fibrosis ... human T cell and tumor cell lines for IO discovery efforts. , ...
Breaking Biology News(10 mins):
(Date:5/8/2019)... ... ... Atlas is on the large side for a Quarter Horse. He and his owner ... When loping around a corner in late 2017, Atlas tripped and partially tore his right ... to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of her veterinarian, Dr. Colter ...
(Date:5/4/2019)... PINE BROOK, N.J. (PRWEB) , ... May 03, ... ... visual electrophysiology, announces the release of the Diopsys® ffERG/Photopic Negative Response ... signs of glaucoma. , By 2050, it is estimated that 6.3 million Americans ...
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – ...
(Date:4/25/2019)... ... ... deaf Great Dane. His owners rescued him when he was four months old from a ... he was always an active and playful pup. Frank bonded with his brother, another Great ... grew, playtime became rougher and Frank ended up injuring his right rear leg. , Frank’s ...
Breaking Biology Technology:
Cached News: