Complex gene-swapping spawns a form of lymphoma

June 28, 2002 -- Researchers have identified how a form of lymphoma develops when large pieces of chromosomes swap locations. Their observations about how chromosome rearrangements, or translocations, cause pro-B cell lymphoma in mice offer a fresh perspective on how cancers arise from an increased "dosage" of specific genes or regions of the genome.

The studies are reported in the June 28, 2002, issue of the journal Cell by Howard Hughes Medical Institute (HHMI) investigator Frederick W. Alt, HHMI associates Chengming Zhu and Kevin D. Mills, and colleagues at Children's Hospital in Boston, Harvard Medical School, the Center for Blood Research, and Brigham and Women's Hospital.

Leukemias and lymphomas can arise when chromosomes inappropriately swap genetic material. After the genetic material is swapped, various genes are removed from their natural context and they propel cell growth because they are no longer under normal control. In some cases, more complex gene translocations (as opposed to swapping one gene for another) lead to amplification of large regions of the genome. Alt and his colleagues coined the term "complicon" -- derived from "complex translocation" -- to describe this phenomenon.

Complicons may develop when the cell's DNA repair mechanisms malfunction. When DNA repair fails, broken chromosomes can persist and recombine inappropriately with other chromosomes. This leads to chromosomal translocations where genes or whole chunks of the genome are swapped from one chromosome to another.

"Complicons are commonly seen in human carcinomas, in which very complex rearrangements cause two genes that are normally on different chromosomes to amplify together," said Alt. "To date, however, there have been no mechanistic studies that have shown how complicons arise."

Alt and his colleagues, who have been studying a specific type of DNA repair pr

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3 4

Related biology news :

1. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
2. UC Riverside to play active role in Institute for Complex Adaptive Matter
3. Complex carbohydrate found to regulate plant growth
4. The Geometry of Ecological Interactions: Simplifying Spatial Complexity
5. Complex mystery of amphibian decline calls for a new kind of science
6. Magnetic Fluids More Complex Than Previously Thought
7. Environmental Testimony: Taiwan Mega-Complex Threatens Endangered Spoonbills And Efforts To Cut Greenhouse Gases, UD Prof Says
8. Researcher Gains 30,000% Saving Using "Bargain Basement" Chemistry To Create Complex Industrially Useful Molecules
9. Second Gene Responsible For Tuberous Sclerosis Complex Identified
10. UCF brain cell research spawns hope for longer life
11. Sturgeon researchers vision spawns thriving industry

Post Your Comments:

(Date:8/6/2019)... ... 2019 , ... VetStem Biopharma has long been ... experience. In November it spun out a human regenerative medicine subsidiary, ... of the first cGMP cell manufacturing facilities in California , VetStem signed ...
(Date:8/6/2019)... ... August 05, 2019 , ... ... announce its attendance at the Microscopy & Microanalysis 2019 Meeting ( M&M 2019 ... Oregon Convention Center. , The Microscopy & Microanalysis Meeting, organized by the Microscopy ...
(Date:8/4/2019)... ... August 02, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL OPERATIONS , August ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An upcoming ... is scheduled to broadcast 4Q/2019. Check your local listings for more information. , ... generic drug delivery. Focusing on therapeutics for children and the elderly, viewers will ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... for sales and service organizations, today announced that the company’s Studio Intelligent ... for the IVA market . Inference will officially accept the award at Frost ...
(Date:8/6/2019)... DIEGO (PRWEB) , ... August 06, 2019 , ... ... Marketing Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast ... further growth. SDBN BUZZ podcast will also serve to promote the region and ...
Breaking Biology Technology:
Cached News: