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Component in plastic bottles found to cause abnormal pregnancies in mice

cleaned with a harsh detergent. The detergent caused BPA to leach from the polycarbonate material used to make the cages and bottles. Over several years, Hunt and her team proceeded to determine how much BPA the mice had been inadvertently exposed to, which was a relatively large amount. Then, they scaled back to see how small a dose would produce effects. This amounted to daily doses of 20 parts/billion over five to seven days, an extremely low level. We cant say anything about the effects of BPA on humans, says Hunt. Nevertheless, the cell division program for eggs is extraordinarily similar in mice and humans, and the results of our studies in mice are disturbing because brief exposure during the final stages of egg growth were sufficient to cause significant increases in meiotic abnormalities.


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Contact: George Stamatis
gxs18@po.cwru.edu
216-368-3635
Case Western Reserve University
31-Mar-2003


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