Component of fly saliva makes promising Leishmaniasis vaccine

Researchers seeking to make a vaccine against a serious parasitic infection have discovered a dose of fly saliva might be just what the doctor ordered. Leishmaniasis, a disabling and sometimes deadly tropical illness, is caused by a parasite transmitted to people through the bite of a sand fly. In a report released today, scientists from the National Institute of Allergy and Infectious Diseases (NIAID) describe how a vaccine they developed against a component of sand fly saliva prevents leishmaniasis in mice.

Leishmaniasis, a major health problem in many tropical and desert climates, has resisted efforts to develop an effective vaccine. "Today's report describes a novel vaccine," says NIAID Director Anthony S. Fauci, M.D. "Rather than targeting the parasite, as is typical, our researchers produced a vaccine to the saliva of the insect that transmits the parasite. This approach could potentially be used to develop vaccines for other insect- or tick-borne diseases."

Leishmaniasis refers to a group of related diseases. Different species of the single-celled parasite Leishmania can cause flesh-eating nose, throat and mouth infections (mucosal leishmaniasis); painful skin lesions (cutaneous leishmaniasis); or fatal infestations of the internal organs (visceral leishmaniasis). An estimated 12 million people currently are affected by one or more of these diseases, most of whom live in South or Central America, Africa and the Middle East.

NIAID's Jos Ribeiro, M.D., Ph.D., an expert on the biochemistry of blood-feeding bugs, has spent more than 30 years studying how components of saliva not only help insects and ticks obtain their blood meals but also modulate the immune response. He and others have previously shown that laboratory animals immunized with sand fly saliva often resist infection when later bitten by a Leishmania-carrying insect, or challenged with parasites in the presence of sand fly saliva. In the new study reported August 6

Contact: Sam Perdue
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2 3

Related biology news :

1. Component in plastic bottles found to cause abnormal pregnancies in mice
2. Largest Study Of Twins Shows Delay In Language Acquisition Has Strong Genetic Component Among Children At Low End Of Developmental Scale
3. Ancient "Jumping DNA" May Have Evolved into Key Component of Human Immune System
4. Researchers Identify New Component Of Circadian Clock
5. Getting At The Components Of Mechanotransduction: Genes Required For Vertebrate Sensory Hair Cell Function Identified
6. Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
7. 3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs
8. Scientists Identify Retrovirus-Like Components In Corn Genome
9. Component In Soy Products May Be Substitute For Estrogen Treatment
10. Bone, enamel, dentine, milk & saliva share gene family
11. Bat saliva drug and new MRI techniques offer hope for acute stroke treatment

Post Your Comments:

(Date:5/23/2017)... Italy , May 23, 2017  Hunova, the first robotic gym ... trunk, has been officially launched in Genoa, Italy . ... Europe and the USA . The technology ... on the market by the IIT spin-off Movendo Technology thanks to a ... the Multimedia News Release, please click: ...
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: