t plans to test his vaccine in dogs-natural reservoirs of the parasite-and monkeys. His team also will look at other Leishmania species and the sand fly species that transmit them, hoping to develop vaccines for other forms of leishmaniasis. In addition, he has begun to study people who are naturally exposed to Leishmania to see which components of fly saliva might protect them from disease. "Different sand fly species, each with its unique collection of salivary proteins, transmit different Leishmania species," he explains. "If anti-saliva vaccines are to work in people, they will have to be specifically engineered for the problem insects of each region."

'"/>

Contact: Sam Perdue
sp189u@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
6-Aug-2001

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