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Computer Simulation Reveals Nano-Switch That Activates Cell-Binding Function Of Key Protein In The Body

as applied, the module otherwise remained intact during the simulation and, thus, is able to rapidly reassemble and restore its cell-binding affinity.

"Our experiment provides the first atomic-scale description of a tension-activated switch for regulating a protein's cell-binding affinity," Vogel says. "This gives totally new insight into how nature may utilize tension to enable a cell to detach itself from the extracellular matrix and move on. The regulation of cell motility is important in, among other things, the development of embryos, wound healing and metastasis of cancer cells.


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Contact: Greg Orwig
gorwig@u.washington.edu
206-543-2580
University of Washington
16-Feb-1999


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