Computer generates comparative gene maps

ITHACA, N.Y. -- Comparing the genomes of two related species of a plant or animal often helps to locate important genes that have been identified in one species but not in another, and can provide clues about how both species evolved from a common ancestor. But making these "comparative gene maps" has been a slow, painstaking process, something biologists do by hand over weeks, months or years, using data painstakingly collected in "wet labs" and analyzed with software designed to interpret only one map at a time.

Now, Cornell University researchers have come up with a way to do the comparison step in a few hours on a computer. In early tests, a computer-generated comparison of the genomes of rice and maize (corn) closely matched a similar map made by hand, and even suggested some relationships that had not shown up in the handmade map.

Debra Goldberg, Cornell graduate student in applied mathematics, developed the new method in collaboration with Susan McCouch, Cornell professor of plant breeding, and Jon Kleinberg, Cornell assistant professor of computer science. Goldberg described their work at the Gene Order Dynamics, Comparative Maps and Multigene Families (DCAF) workshop held September in Sainte-Adèle, Quebec, and will present a later version at the Plant and Animal Genome IX conference in San Diego in January. Their paper, "Algorithms for Constructing Comparative Maps," appears in Comparative Genomics (David Sankoff and Joseph H. Nadeau, Eds., Kluwer Academic Publishers, 2000). A software implementation of the new method soon will be available to geneticists.

"The point of this isn't just to compare rice and corn, but to be able to do it with any two species," Goldberg says. "Ideally we'd like to be able to find new evolutionary pathways."

Every so often, as reproductive cells divide, genes and segments of chromosomes get shuffled around. One chromosome meets another and pieces of DNA are moved or swapped. If those particular c

Contact: Bill Steele
Cornell University News Service

Page: 1 2 3 4

Related biology news :

1. Computer scientists at UH developing nurturing computers
2. Computer models expose humans as main cause of caribou decline
3. Computer database being developed at Temple will allow for better inventory of chemicals
4. Computer imaging of Archeopteryx skull suggests this dinosaur-bird link could fly
5. Computer model shows increased US threat from soybean rust
6. 20 May AAAS lecture: Computers that Respond to Human Emotion
7. Computer modeling targets epidemics, bioterror
8. Computer method identifies potentially active enzymes
9. Computer scientists develop tool for mining genomic data
10. Computer model offers new tool to probe Woburn toxic waste site
11. Computer models forecast sharp increase in temperature if heat-trapping emissions continue to rise

Post Your Comments:
TAG: Computer generates comparative gene maps

(Date:10/5/2015)... -- http://soundview.co ) releases the ... NXTD ), a biometric authentication company focused on ... ) releases the following market and company ... biometric authentication company focused on the growing mobile commerce ... ) releases the following market and company ...
(Date:9/30/2015)... , Sept. 30, 2015  The global glucose monitoring device ... 2015. So says a new report on the industry from ... segment dominate the market, followed by continuous glucose monitoring and ... on the market for these products in its latest report, ... , ...
(Date:9/28/2015)... 28, 2015 The global ... USD 12.03 billion by 2020, growing at a CAGR ... as Backside Illumination (BSI) technique to improve picture quality ... period.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757) , ... to reduce loss and, thus, reduce the noise interference ...
Breaking Biology News(10 mins):
(Date:10/8/2015)... BALTIMORE, Maryland , October 8, 2015 /PRNewswire/ ... http://www.GoldmanResearch.com .   --> Goldman ... specializing in the small cap and microcap sectors, ... sponsored research report on PharmaCyte Biotech, Inc. (OTCQB ... company focused on developing and preparing treatments for ...
(Date:10/8/2015)... 8, 2015  The ALS Association, in partnership with ... Challenge to revolutionize communication technology solutions for people living ... ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative ... and the spinal cord. Eventually, people with ALS lose ... often leads to total paralysis and death within two ...
(Date:10/8/2015)... ... , ... Talon Innovations, a provider of Precision Machined Products and ... is one of three finalists for the Minnesota Business magazine’s Manufacturing Award in the ... Innovations was recognized as a nominee for this competitive award. , The “Best ...
(Date:10/7/2015)... 7, 2015 Boston Scientific (NYSE: ... the Boston Scientific Connected Patient Challenge , an ... use of remote patient monitoring to enhance patient care.  ... can submit their ideas and collaborate on solutions through ... Cambridge, MA where they ...
Breaking Biology Technology:
Cached News: