HOME >> BIOLOGY >> NEWS
Computer generates comparative gene maps

ITHACA, N.Y. -- Comparing the genomes of two related species of a plant or animal often helps to locate important genes that have been identified in one species but not in another, and can provide clues about how both species evolved from a common ancestor. But making these "comparative gene maps" has been a slow, painstaking process, something biologists do by hand over weeks, months or years, using data painstakingly collected in "wet labs" and analyzed with software designed to interpret only one map at a time.

Now, Cornell University researchers have come up with a way to do the comparison step in a few hours on a computer. In early tests, a computer-generated comparison of the genomes of rice and maize (corn) closely matched a similar map made by hand, and even suggested some relationships that had not shown up in the handmade map.

Debra Goldberg, Cornell graduate student in applied mathematics, developed the new method in collaboration with Susan McCouch, Cornell professor of plant breeding, and Jon Kleinberg, Cornell assistant professor of computer science. Goldberg described their work at the Gene Order Dynamics, Comparative Maps and Multigene Families (DCAF) workshop held September in Sainte-Adèle, Quebec, and will present a later version at the Plant and Animal Genome IX conference in San Diego in January. Their paper, "Algorithms for Constructing Comparative Maps," appears in Comparative Genomics (David Sankoff and Joseph H. Nadeau, Eds., Kluwer Academic Publishers, 2000). A software implementation of the new method soon will be available to geneticists.

"The point of this isn't just to compare rice and corn, but to be able to do it with any two species," Goldberg says. "Ideally we'd like to be able to find new evolutionary pathways."

Every so often, as reproductive cells divide, genes and segments of chromosomes get shuffled around. One chromosome meets another and pieces of DNA are moved or swapped. If those particular c
'"/>

Contact: Bill Steele
ws21@cornell.edu
607-255-7164
Cornell University News Service
20-Dec-2000


Page: 1 2 3 4

Related biology news :

1. Computer scientists at UH developing nurturing computers
2. Computer models expose humans as main cause of caribou decline
3. Computer database being developed at Temple will allow for better inventory of chemicals
4. Computer imaging of Archeopteryx skull suggests this dinosaur-bird link could fly
5. Computer model shows increased US threat from soybean rust
6. 20 May AAAS lecture: Computers that Respond to Human Emotion
7. Computer modeling targets epidemics, bioterror
8. Computer method identifies potentially active enzymes
9. Computer scientists develop tool for mining genomic data
10. Computer model offers new tool to probe Woburn toxic waste site
11. Computer models forecast sharp increase in temperature if heat-trapping emissions continue to rise

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Computer generates comparative gene maps

(Date:4/17/2014)... German . Our ... provide us with a continuous stream of information about our ... still in a car the world glides by us ... without effort, our brain calculates self-motion from this "optic flow". ... steady gaze during our own movements. Together with biologists from ...
(Date:4/17/2014)... German . If ... of him, he can expect his premises to be trashed. ... the consequences is enough to make restaurant owners pay up. ... their eggs in other birds, nests. If the host birds ... revenge by destroying the entire nest. Consequently, it is beneficial ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Methane climate change risk suggested by proof of redox cycling of humic substances 2
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... 13, 2014 Bob Hainsey, a semiconductor ... 20 years in the industry, has joined SPIE, ... will serve as the society’s Science and Technology Strategist. ... SPIE as our Technology Strategist, further strengthening the technical ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
Cached News: