HOME >> BIOLOGY >> NEWS
Computer method identifies potentially active enzymes

Better drugs, improved industrial applications and even cleaner laundry may be possible with a new computer method to predict which hybrid enzymes are likely to have high activity, according to a team of Penn State chemists and chemical engineers.

"FamClash is quite successful at qualitatively predicting the pattern of the specific activity of the hybrids," the researchers report in this week's online issue of the Proceedings of the National Academy of Sciences. "By identifying incompatible residue pairs in the hybrids, this method provides valuable insights for protein engineering interventions to remedy these clashes," the researchers say. FamClash is a computer method used to predict which hybrid enzymes are likely to have activity and which are not. Hybrid enzymes form when researchers combine similar enzymes from two or more different organisms. The variant enzymes are broken and recombined with parts from the original enzymes creating the new one.

"We have worked out ways to make libraries of novel enzymes by splicing proteins together," says Alexander R. Horswill, postdoctoral fellow in chemistry. "We wanted to know how active the new enzymes would be compared to the wild type."

Industrial processes use enzymes when reactions are too slow or too expensive to carry out without a catalytic boost. The most familiar use of enzymes is in laundry detergents where dirt-removing enzymes can gobble up stains even in cold water.

" It is hard to create an enzyme that is better than what occurs in nature," says Horswill. "But the FamClash approach will aid in engineering enzymes to work better in unnatural conditions, such as low or high temperatures, basic or acidic environments or organic solvents."

Horswill and Stephen J. Benkovic, the University professor, the Evan Pugh Professor of Chemistry and holder of the Eberly Chair in Chemistry, used enzymes from Escherichia coli and Bacillus subtilis, two common bacteria. Both p
'"/>

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
23-Feb-2004


Page: 1 2 3

Related biology news :

1. Computer scientists at UH developing nurturing computers
2. Computer models expose humans as main cause of caribou decline
3. Computer database being developed at Temple will allow for better inventory of chemicals
4. Computer imaging of Archeopteryx skull suggests this dinosaur-bird link could fly
5. Computer model shows increased US threat from soybean rust
6. 20 May AAAS lecture: Computers that Respond to Human Emotion
7. Computer modeling targets epidemics, bioterror
8. Computer scientists develop tool for mining genomic data
9. Computer model offers new tool to probe Woburn toxic waste site
10. Computer models forecast sharp increase in temperature if heat-trapping emissions continue to rise
11. Computer scientist locates more than 1,000 novel genes in mouse and human

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... They call it the “hairy ball.” ... depiction of a system of linkages and connections so complex and dense that ... computer science at Worcester Polytechnic Institute (WPI) and director of the university’s bioinformatics ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... announced today that they have entered into a multiyear collaboration to identify and ... researchers with additional tools for gene editing across all applications. , Under the ...
(Date:10/12/2017)... ca (PRWEB) , ... October 12, 2017 , ... ... the Surgical Wound Market with the addition of its newest module, US Hemostats ... $1.2B market for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
Breaking Biology Technology:
Cached News: