HOME >> BIOLOGY >> NEWS
Computer scientist locates more than 1,000 novel genes in mouse and human

Using both the mouse and human genomes, a computer scientist at Washington University in St. Louis and international collaborators have developed a method for predicting novel genes in both genomes. With the method the scientists have discovered 1,019 novel genes that are found in both man and mouse. The breakthrough is expected to speed up discovery of genes in both genomes as well as those of other mammals. Because it is efficient and cost-effective, laboratories are likely to use it and pursue genetic studies on a number of major fronts.

"Whereas it might have taken 7,000 experiments to verify a thousand genes, with our method it now will take only about 1,500," said Michael R. Brent, Ph.D., associate professor of computer science at Washington University in St. Louis.

Brent developed TWINSCAN, one of the programs used to predict genes by looking at both the alignment between the two genomes and statistical patterns in the individual DNA sequences of each genome. DNA is comprised of four varieties of bases (commonly abbreviated as A, T, G, C). The myriad different arrangements of these base pairings -- or sequences -- are the instructions for making proteins, which in turn give physiological traits such as color, hair type, muscle variations, etc. DNA looks like a long string of unintelligible pairings, but programs such as Brent's highlight the genes in the sequence, making sense of it for biomedical researchers.

Simply put, what Brent and his colleagues did was develop computer programs that use patterns of evolutionary conservation -- DNA sequences that have not changed since the common ancestor of mouse and man -- to improve the accuracy of gene prediction. They identified a set of 1,019 predicted novel mouse genes and showed that genes in this set can be verified experimentally with a very high success rate.

A paper describing the results was published in the Feb. 4, 2003, issue of the Proceedings of the National Academy of Scie
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@aismail.wustl.edu
314-935-5272
Washington University in St. Louis
4-Feb-2003


Page: 1 2 3

Related biology news :

1. Computer scientists at UH developing nurturing computers
2. Computer models expose humans as main cause of caribou decline
3. Computer database being developed at Temple will allow for better inventory of chemicals
4. Computer imaging of Archeopteryx skull suggests this dinosaur-bird link could fly
5. Computer model shows increased US threat from soybean rust
6. 20 May AAAS lecture: Computers that Respond to Human Emotion
7. Computer modeling targets epidemics, bioterror
8. Computer method identifies potentially active enzymes
9. Computer scientists develop tool for mining genomic data
10. Computer model offers new tool to probe Woburn toxic waste site
11. Computer models forecast sharp increase in temperature if heat-trapping emissions continue to rise

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Mitotech S.A, ... with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and Dermatology, announced ... SkQ1 ophthalmic solution in patients with moderate to severe Dry Eye Disease ...
(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a biopharmaceutical cold ... Inc. 5000 list. The list is the most prestigious ranking of the nation’s fastest-growing ... for this year’s list, reported three-year revenue growth of 71 percent. , The ...
(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage ... Food and Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) ... severe COVID-19. Approval of this IND allows Sentien to initiate a Phase 1/2 ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... LEXINGTON, Mass. (PRWEB) , ... August 11, 2020 ... ... awarded $300,000 a year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial ... year in 2021 and 2022. The network is a consortium of academic research ...
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. ... a global leader in FDA compliance consulting has been named on its annual ... The list represents a unique look at the most successful companies within the ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, the global ... has been named one of the 100 most inspiring individuals in the life-sciences ... are selected based on how they have inspired their colleagues and affected positive ...
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive four ... may choose which extremities they would like treated. , Several studies have shown just ... R3 International, umbilical cord tissue is obtained from a lab with a long history ...
Breaking Biology Technology:
Cached News: