HOME >> BIOLOGY >> NEWS
Computing the connections between proteins

Searching for a soul mate, new friends, or just fresh contacts? Turns out that proteins have similar "goals." However, shaking off their single status generally doesn't come easy.

Biochemist, turned protein matchmaker, Dr. Gideon Schreiber of the Weizmann Institute of Science and doctoral student Tziki Seltzer, took their fate to heart. Working with colleagues at the Biological Chemistry Department, they developed a computer algorithm which calculates the rate at which two proteins associate, using it to fashion proteins with increased affinity - of a hundred times or more. Their achievement, recently appearing in Nature Structural Biology, holds much promise for the pharmaceutical and food industries, since protein complexes are fundamental to many life processes.

Protein affinity is defined by the rate at which two proteins associate with one another to form a complex, divided by the rate at which this complex dissociates. In order to improve protein affinity one can either intervene to reduce protein "break-up" statistics, or alternatively, increase protein association rates. Dr. Schreiber chose the latter.

Since association rates are influenced by the protein's (genetically determined) design, the scientists used this relationship as their guiding principle - developing an algorithm capable of determining the genetic changes necessary to boost association rates.

Dr. Schreiber: "A common approach to improving protein affinity is to create a large pool of mutations and discover the optimal complex through trial and error. However, the possibilities are often endless. Computer simulations are far more efficient in pinpointing potentially successful complexes."

Using the algorithm, the researchers significantly increased the production rate and strength of a specific protein complex. The new protein match-up system may lead to diverse medicinal applications based on increasing or inhibiting protein activity, as well as new diag
'"/>

Contact: Jeffrey Sussman
jeffrey@acwis.org
212-895-7951
American Committee for the Weizmann Institute of Science
19-Jul-2000


Page: 1 2

Related biology news :

1. Yale researcher receives $1.3 million NIH grant to build Center of Excellence in Biomedical Computing
2. Rutgers to start up National Program of Excellence in Biomedical Computing
3. Computing device to serve as basis for biological computer
4. Molecule awakens and maintains neural connections
5. Gene essential for development of normal brain connections resulting from sensory input discovered
6. K-State professor examines connections between food, culture and psychology in new book
7. New studies reveal connections between oceanographic processes and rockfish populations
8. Pictures reveal how nerve cells form connections to store short- and long-term memories in brain
9. Memory mechanism found at nerve cell connections in the brain
10. Family connections feed eating disorders research
11. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... -- Pendant Biosciences, Inc. (formerly Nanoferix, Inc.), a privately-held advanced ... technologies, today announced that it has been accepted into ... . Shawn Glinter , Founder ... are excited to become part of the JLABS @ ... to be the first Tennessee -based ...
(Date:4/26/2017)... ... 26, 2017 , ... WonderWorks, Myrtle Beach’s science focused amusement ... of deep space exploration and inspire space enthusiasts. The exhibit features interactive exhibits ... guest appearance by former Shuttle Astronaut Don Thomas. , The intergalactic weekend kicks ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... its new Bioflash MailGuardtm mail security screening solution at the National Postal Forum ... MailGuard system provides a fast, highly accurate, easy to use and low cost ...
(Date:4/26/2017)... 2017  Genisphere LLC, provider of the 3DNA ... collaborative and sponsored research agreement with the University ... The overall goal of the partnership is to ... designs and formulations after in vivo ... vasculature as well as inflammatory responses, demonstrating various ...
Breaking Biology Technology:
Cached News: