HOME >> BIOLOGY >> NEWS
Constructing "Designer" Plant Enzymes

Chris Somerville, director of the Carnegie Institution's Department of Plant Biology, Pierre Broun, a former postdoctoral fellow at the department, and John Sahanklin and Ed White of the Brookhaven National Laboratory report in the November 13 issue of Science on their experimental successes with directed interconversions of enymes that modify plant fatty acids. Their results represent a step toward the production of novel plant fatty acids by genetic manipulations.

In their experiments, Somerville, Broun, and colleagues uncovered a surprising "plasticity" in enzymes, a property that one day might lead to creation of enzymes that have not been found in nature. The work has important implications for the development of useful new chemicals from plants, such as the production of novel diacids for use in high-temperature lubricants or as feedstocks for polyamide synthesis.

The Carnegie/Brookhaven team reported the directed conversion of a fatty acid desaturase into a fatty acid hydroxylase. The research group was also successful in doing the converse: converting a hydroxyase into a desaturase by making as few as six amino acid changes. In addition, Somerville and colleagues proposed that amino acid variations in the same enzyme can cause the formation of triple bonds and epoxy groups. Thus, this discovery reveals the chemical mechanisms responsible for the formation of most of the chemical diversity found in plant fatty acids. "Basically," says Somerville, "the underlying chemical reaction is very promiscuous and the enzymes have harnessed this 'catalytic promiscuity' to create a huge amount of diversity." The discovery raises the possibility that it may be possible to create a family of novel synthetic enzymes that produce industrially useful fatty acids with a wide range of chemical structures.


'"/>

Contact: Pat Craig
pcraig@pst.ciw.edu
202-939-1120
Carnegie Institution
12-Nov-1998


Page: 1

Related biology news :

1. Plants will not save us from greenhouse gases
2. Plant pathologists meeting in Anaheim, CA to discuss agricultural security, food safety, and more
3. Plant gene discovery could enhance plant growth, reduce fertilizer needs and phosphate pollution
4. Plant respiration not just an evolutionary leftover, study shows
5. Canadian Society of Agronomy partners with Plant Management Network
6. Plant pathologists look to forensics to aid in biosecurity
7. Plants for the future: A European vision for plant biotechnology towards 2025
8. Plant pathologists to discuss the future of organic farming
9. Plant pathologists to meet in Anaheim, CA to discuss agricultural security, food safety, and more
10. Plant-like enzyme acts as key life cycle switch in malaria parasite
11. Plant disease under the homeland security microscope

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments ... consulting, Nanoscience Analytical offers a broad range of contract analysis services for ...
Breaking Biology Technology:
Cached News: