HOME >> BIOLOGY >> NEWS
Continued Prophylactic Treatment Of P. Marneffei Can Prevent Relapse

A large number of patients in Thailand who are infected with the Human Immunodeficiency Virus (HIV) have become ill from a previously very rare fungus called Penicillium Marneffei. Giving prophylactic itraconazole, an anti-fungal drug, to patients who have been treated for P. Marneffei, a potentially fatal fungal infection, can prevent a relapse of the infection. In a study of patients with HIV infection who responded to primary treatment for Penicillium Marneffei, researchers from the Johns Hopkins School of Public Health and Chiang Mai University in Thailand successfully administered itraconazole and prevented the recurrence of P. Marneffei. The study was published in the December 10, 1998 issue of The New England Journal of Medicine.

Kenrad Nelson, MD, professor, Epidemiology, Johns Hopkins School of Public Health said, "The relapse rate for P. Marneffei is about 50 percent in those patients without continued preventive treatment. We wanted to find a preventive treatment that was highly effective and well tolerated. We didn't expect the drug would work as well as it did." Dr. Nelson's team looked at 71 HIV- positive patients in Thailand who had received treatment for P. Marneffei. Half of them received itraconazole and half received a placebo. Twenty of those in the placebo group, more than half, had a relapse of P. Marneffei during the course of the study. None of those treated with itraconazole had a relapse. The median time to relapse was 24 weeks.

In northern Thailand, P. Marneffei is the third most common opportunistic infection in HIV patients. The infection causes weight loss, fever, anemia, and skin lesions. It has a 20% fatality rate even with appropriate treatment but is 100% fatal if not diagnosed and treated. Preventing relapse is highly preferable to treatment since some relapses can not be treated successfully. Dr. Nelson said, "This regimen should be the standard of care for patients with AI
'"/>

Contact: Kathi Moore
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
10-Dec-1998


Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment stimulates growth and regeneration of injured adult skeletal muscle
3. Treatment of lupus in mice may point the way to human treatment
4. Treatment in mice proves effective against Duchenne muscular dystrophy
5. Treatment protects mouse ovaries from radiation therapy
6. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
7. Treatment restores normal heart rhythm in patients
8. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
9. Researchers: Exciting Discovery Might Improve Cancer Treatment
10. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
11. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... April 24, 2017 Janice Kephart ... with  Identity Strategy Partners, LLP (IdSP) , today ... without President Trump,s March 6, 2017 Executive ... , refugee vetting can be instilled with greater confidence, ... now, all refugee applications are suspended by until ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/9/2017)... , ... October 09, 2017 , ... At its national ... Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has been ... a member of the winning team for the 2015 Breakthrough Prize in Fundamental physics ...
Breaking Biology Technology:
Cached News: