HOME >> BIOLOGY >> NEWS
Continued Prophylactic Treatment Of P. Marneffei Can Prevent Relapse

A large number of patients in Thailand who are infected with the Human Immunodeficiency Virus (HIV) have become ill from a previously very rare fungus called Penicillium Marneffei. Giving prophylactic itraconazole, an anti-fungal drug, to patients who have been treated for P. Marneffei, a potentially fatal fungal infection, can prevent a relapse of the infection. In a study of patients with HIV infection who responded to primary treatment for Penicillium Marneffei, researchers from the Johns Hopkins School of Public Health and Chiang Mai University in Thailand successfully administered itraconazole and prevented the recurrence of P. Marneffei. The study was published in the December 10, 1998 issue of The New England Journal of Medicine.

Kenrad Nelson, MD, professor, Epidemiology, Johns Hopkins School of Public Health said, "The relapse rate for P. Marneffei is about 50 percent in those patients without continued preventive treatment. We wanted to find a preventive treatment that was highly effective and well tolerated. We didn't expect the drug would work as well as it did." Dr. Nelson's team looked at 71 HIV- positive patients in Thailand who had received treatment for P. Marneffei. Half of them received itraconazole and half received a placebo. Twenty of those in the placebo group, more than half, had a relapse of P. Marneffei during the course of the study. None of those treated with itraconazole had a relapse. The median time to relapse was 24 weeks.

In northern Thailand, P. Marneffei is the third most common opportunistic infection in HIV patients. The infection causes weight loss, fever, anemia, and skin lesions. It has a 20% fatality rate even with appropriate treatment but is 100% fatal if not diagnosed and treated. Preventing relapse is highly preferable to treatment since some relapses can not be treated successfully. Dr. Nelson said, "This regimen should be the standard of care for patients with AI
'"/>

Contact: Kathi Moore
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
10-Dec-1998


Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment stimulates growth and regeneration of injured adult skeletal muscle
3. Treatment of lupus in mice may point the way to human treatment
4. Treatment in mice proves effective against Duchenne muscular dystrophy
5. Treatment protects mouse ovaries from radiation therapy
6. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
7. Treatment restores normal heart rhythm in patients
8. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
9. Researchers: Exciting Discovery Might Improve Cancer Treatment
10. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
11. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... ... , ... Greffex, a pioneering vaccine and gene therapy company based in Houston, ... need for a global perspective to make an impact in a post pandemic world,” ... as an independent, director of the company. , “The Greffex board is excited to ...
(Date:5/28/2020)... ... May 28, 2020 , ... ... announced a new enzyme solution for adjunct liquefaction: AMYLEX® 6T. The innovative ... ability to expand into new segments with locally-sourced raw materials, improve productivity, ...
(Date:5/21/2020)... , ... May 19, 2020 ... ... leading software-as-a-service (SaaS) provider of operations management solutions, today introduced BioMed to ... provides a cloud-based platform for connecting the people and systems around biomedical ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 22, 2020 , ... Regen Suppliers, the one stop ... buy three, get the fourth unit free with no limit on the amniotic ... as exosomes, have been a game changer for regenerative therapies. The products are ...
(Date:6/19/2020)... ... June 18, 2020 , ... The Vitaspace ... is to join forces to radically prolong life and find a way (medicine or ... period. This project was supported by various scientists from all over the world, doctors, ...
(Date:6/11/2020)... ... June 09, 2020 , ... TRX Systems, developer of ... Solution, a highly accurate, contact tracing solution for identification of employees who ... a core disease control measure, is a key strategy for preventing further spread ...
(Date:6/2/2020)... ... June 01, 2020 , ... As part of its ongoing ... the world, enterprise security solutions provider bitsIO donated time to help two companies ... during self-quarantines and shelter-in-place orders, companies are increasingly concerned about the security of ...
Breaking Biology Technology:
Cached News: