HOME >> BIOLOGY >> NEWS
Control of intestinal inflammation by PGE2 and its receptor

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have as a common side effect the ability to damage the lining of the intestine. Since NSAIDs inhibit prostanoid biosynthesis, it is accepted that the gastric complications reflect a protective role of some prostaglandins in suppressing intestinal inflammation and damage. Still, the identity of the relevant prostaglandins has not been known, and the involvement of multiple prostaglandin receptors in this beneficial response could not be excluded. Now, however, Kabashima et al. provide a surprisingly simple answer. Taking advantage of the many mouse knockout strains available that lack one or another of the prostaglandin receptors, they show that the prostaglandin PGE2, acting through a single receptor, EP4, is largely if not single-handedly responsible for maintaining the integrity of the intestinal mucosa. While EP4-deficient mice do not ordinarily show symptoms of colitis, the authors find that they are hypersensitive to damage by low doses of the proinflammatory compound dextran sodium sulfate-- doses that are well tolerated by wild-type mice and by animals with mutations in the other receptor genes. Conversely, NSAID treatment, coupled with low-dose DSS, can cause acute disease even in wild-type mice, but treatment with a specific EP4 agonist prevents this response. Hence, this class of agonist might be useful in protecting humans from NSAID gastrotoxicity and might also prove beneficial for ulcerative colitis and Crohn disease, conditions where the gastric mucosa is prone to inflammation and tissue damage.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Mar-2002


Page: 1

Related biology news :

1. Controlling biomolecules with magnetic tweezers
2. Controlling the internal clock in darkness
3. Controlling body size by regulating the number of cells
4. Controlling cell adhesion: Researchers report first evidence of catch bonds
5. Control of fat cell development demonstrated using Sangamo BioSciences ZFP technology
6. Controlled nerve growth factor aids brain cell transplant
7. Controlling greenhouse gas carbon dioxide through carbon sequestration two-day symposium, April 2-3
8. New Gene Holds Promise For Controlling Crohns And Other Inflammatory Diseases
9. Researchers Discover Fast Efficient, Controllable Way To Study Molecular Interactions
10. Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs
11. Dual Control Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/14/2016)... http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ( ... --> DERMALOG, le leader de l,innovation ... d,empreintes digitales pour l,enregistrement des réfugiés en Allemagne. ... produire des cartes d,identité aux réfugiés. DERMALOG dévoilera ...
(Date:3/10/2016)... 10, 2016   Unisys Corporation (NYSE: UIS ... (CBP) is testing its biometric identity solution at the ... to help identify certain non-U.S. citizens leaving the country. ... designed to help determine the efficiency and accuracy of using ... and will run until May 2016. --> ...
(Date:3/8/2016)... , March 8, 2016   Valencell , ... today announced it has secured $11M in Series ... Tech, a new venture fund being launched by ... participation from existing investors TDF Ventures and WSJ ... to continue its triple-digit growth and accelerate its ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a rising hotspot ... rated one of its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, ... unique and intimate team-building experience. , Each event kicks off with an olive oil ...
(Date:5/25/2016)... ... ... Scientists at the University of Athens say they have evidence that the variety of ... could lead to one good one. Surviving Mesothelioma has just posted an article on ... evaluated 98 mesothelioma patients who got a second kind of drug therapy ...
(Date:5/24/2016)... , May 24, 2016   MedyMatch Technology Ltd ... with artificial intelligence, real-time decision support tools in the emergency ... at the 2016 Israeli Advanced Technology Industries (IATI) BioMed Conference. ... Israel,s 15th National Life Sciences and Technology ... the David Intercontinental Hotel in Tel Aviv, Israel ...
(Date:5/23/2016)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a global ... Directors has approved the payment of a quarterly cash dividend ... The cash dividend of $0.24 per share will be ... record as of the close of business on June 24, ... the Board of Directors and may be adjusted as business ...
Breaking Biology Technology:
Cached News: