HOME >> BIOLOGY >> NEWS
Control of intestinal inflammation by PGE2 and its receptor

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have as a common side effect the ability to damage the lining of the intestine. Since NSAIDs inhibit prostanoid biosynthesis, it is accepted that the gastric complications reflect a protective role of some prostaglandins in suppressing intestinal inflammation and damage. Still, the identity of the relevant prostaglandins has not been known, and the involvement of multiple prostaglandin receptors in this beneficial response could not be excluded. Now, however, Kabashima et al. provide a surprisingly simple answer. Taking advantage of the many mouse knockout strains available that lack one or another of the prostaglandin receptors, they show that the prostaglandin PGE2, acting through a single receptor, EP4, is largely if not single-handedly responsible for maintaining the integrity of the intestinal mucosa. While EP4-deficient mice do not ordinarily show symptoms of colitis, the authors find that they are hypersensitive to damage by low doses of the proinflammatory compound dextran sodium sulfate-- doses that are well tolerated by wild-type mice and by animals with mutations in the other receptor genes. Conversely, NSAID treatment, coupled with low-dose DSS, can cause acute disease even in wild-type mice, but treatment with a specific EP4 agonist prevents this response. Hence, this class of agonist might be useful in protecting humans from NSAID gastrotoxicity and might also prove beneficial for ulcerative colitis and Crohn disease, conditions where the gastric mucosa is prone to inflammation and tissue damage.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Mar-2002


Page: 1

Related biology news :

1. Controlling biomolecules with magnetic tweezers
2. Controlling the internal clock in darkness
3. Controlling body size by regulating the number of cells
4. Controlling cell adhesion: Researchers report first evidence of catch bonds
5. Control of fat cell development demonstrated using Sangamo BioSciences ZFP technology
6. Controlled nerve growth factor aids brain cell transplant
7. Controlling greenhouse gas carbon dioxide through carbon sequestration two-day symposium, April 2-3
8. New Gene Holds Promise For Controlling Crohns And Other Inflammatory Diseases
9. Researchers Discover Fast Efficient, Controllable Way To Study Molecular Interactions
10. Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs
11. Dual Control Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Control intestinal inflammation PGE2 and its receptor

(Date:7/29/2014)... latest research from the University of Adelaide ... of many preterm children can perform almost as well as ... University,s Robinson Research Institute has found that as ... early life, their cognitive abilities as a teenager can potentially ... results of the study, published in this month,s issue of ...
(Date:7/28/2014)... U.S. Food and Drug Administration (FDA) for other purposes ... inside human cells, including those that cause Legionnaires, disease, ... mBio , the online open-access journal of the ... identifying non-antibiotic drugs that could one day help curb ... the list inhibit the growth of at least three ...
(Date:7/28/2014)... and organic compounds in hydrothermal environments are critical components ... for the deep biosphere, and may have implications for ... about how minerals influence organic reactions. A team ... a common mineral acts as a catalysts for specific ... solvents or expensive reagents. , At the heart of ...
Breaking Biology News(10 mins):Preterm children's brains can catch up years later 2New route to identify drugs that can fight bacterial infections 2Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
(Date:7/29/2014)... HOUSTON (July 29, 2014) Tough, ultralight foam ... and shape through a chemical process invented at Rice ... "GO-0.5BN" looks like a nanoscale building, with floors and ... a pair of two-dimensional materials: floors and walls of ... boron nitride platelets. , The researchers say the ...
(Date:7/29/2014)... DALLAS , July 29, 2014 ... Market Slide Scanners (Whole Slide Imaging), Analytics (Image Analysis Software), ... Storage - Global Forecasts & Trends to 2018", published ... and restraints in geographies such as North ... Asia , and the Rest of the ...
(Date:7/29/2014)... HILLS, Calif. , July 29, 2014 /PRNewswire/ ... specializing in personalized medicine, treatment of infectious diseases ... strategies of prognosis and prevention of pathologies like ... of August 1, 2014, ImmunoClin Corporation will complete ... Washington, D.C. , a key ...
(Date:7/29/2014)... 2014  Sigma-Aldrich Corporation (NASDAQ: SIAL ) ... its investment in Green Chemistry and donated more than ... year, the Company announced Monday in its new ... World? The report comes in a ... a responsible corporate citizen, including recognition for the second ...
Breaking Biology Technology:Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3
Cached News: