HOME >> BIOLOGY >> NEWS
Controlling body size by regulating the number of cells

Why are elephants bigger than mice? The main reason is that mice have fewer cells. Research published in Journal of Biology this week uncovers a key pathway that controls the number of cells in an animal, thereby controlling its size.

Ernst Hafen and his colleagues from the University of Zrich used fruit flies to investigate the role of the insulin-signalling pathway and in particular a molecule called FOXO. If insulin signalling is reduced, for example by starving developing fly larvae, FOXO activity increases; this then reduces the number of cells in the developing flies, causing them to be smaller.

Mammals have similar a signalling pathway, and it has been suggested to have a role in tumour formation. Hafen's work gives us more insights into how disruption of FOXO function can lead to cancer.

The researchers used a combination of genetic techniques, over expressing FOXO in parts of the fly and analysing flies that contained no functional FOXO protein, to investigate what FOXO does. They found that flies with no functional FOXO looked normal but were more sensitive to oxidative stress, thought to be a cause of ageing. Increasing the amounts of highly active FOXO protein in the developing fly eye caused many of the eye cells to die. However, the real clue to FOXO's function came from studying the effect of removing functional FOXO protein from flies that have a reduced ability to signal downstream of insulin.

Normally, reducing insulin signalling in developing flies causes these flies to become smaller as they have fewer, smaller cells. Yet without FOXO, these flies do not suffer such a severe size reduction. This is because they have more cells than normal insulin signalling pathway mutants. These experiments suggest that FOXO plays a role in reducing the number of cells in the developing fly if insulin is not present, by inhibiting cell division.

Hafen and his co-authors write, "In this study we provide genetic
'"/>

Contact: Gemma Bradley
press@biomedcentral.com
44-207-323-0323
BioMed Central
6-Aug-2003


Page: 1 2

Related biology news :

1. Controlling biomolecules with magnetic tweezers
2. Controlling the internal clock in darkness
3. Controlling cell adhesion: Researchers report first evidence of catch bonds
4. Controlling greenhouse gas carbon dioxide through carbon sequestration two-day symposium, April 2-3
5. New Gene Holds Promise For Controlling Crohns And Other Inflammatory Diseases
6. Controlling Problem Snakes: Saipan Benefits From USGS Research
7. New Discovery Offers Hope For Controlling Cholesterol, Atherosclerosis
8. Boosting Immune Response Against HIV-1 Key To Controlling Infection, Say University Of Pittsburgh Researchers
9. R-Type Channels - A New Type Of Calcium Channels Controlling Signal Transduction Between Neurons In The Brain
10. Curing Malaria, Controlling Mosquitoes Symposium Set For AAAS Meeting
11. Two Parasitic Wasps Show Promise For Controlling Pest Flies

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Controlling body size regulating the number cells

(Date:12/3/2014)... , Dec. 2, 2014 As part ... readers, Inception Technologies is pleased to announce the release ... for customers to collect the workforce data that they ... that have been left by existing readers. Many such ... interface, connectivity and modern technology. Older models force users ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure ... Industry Association today jointly announce the formation of ... release of its Identity and Biometric Entry ... The Framework received official support from BORDERPOL, the ... to improve and provide expertise regarding border security, ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
(Date:12/19/2014)... December 18, 2014 LayerBio is an ... and wound care. The National Eye Institute (NEI) at ... a Phase I SBIR grant to develop a drug-eluting ... the most common cause of vision loss in people ... worldwide. According to Dr. Ken Mandell, LayerBio’s Founder and ...
(Date:12/19/2014)... iLab Solutions, the global leader in core facility ... the new Director of Institutional Implementations and Sarah Becker ... new leadership positions were created to support iLab’s mission ... continues to meet the needs of its growing customer ... been deployed at over 450 core facilities across more ...
(Date:12/19/2014)... San Diego, CA (PRWEB) December 18, 2014 ... announces a limited time special on Sartorius Biohit ... 1 Free on mLINE pipettes, Picus Electronic Pipette Trade-in ... recommended by Health and Safety officers around the world. ... repetitive manual pipetting. Other features include:, , ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
Cached News: