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Controlling the internal clock in darkness

How do people subjected to the endless dark days of winter in the far northern latitudes maintain normal daily rhythms? Though many might feel like hibernating, a highly regulated internal system keeps such impractical yearnings in check. From fruit flies to humans, nearly every living organism depends on an internal clock to regulate basic biological cycles such as sleep patterns, metabolism, and body temperature. And that clock runs on similar molecular mechanisms.

Specific clusters of neurons in the brain are known to control the biological clock. Scientists believed these brain "clock cells" function as independent units. But new research described in this issue show that the neurons do not act in isolation; rather they collaborate with other neurons in a cell-communication network to sustain the repeating circadian rhythm cycles.

Clock cells within the brain maintain an organism's circadian rhythms, even in the absence of cyclical environmental signals like light, in a state scientists call "free running." Though it has long been clear that the circadian rhythms of an organism persist under such free-running conditions (for example, constant darkness), it was thought that the gene-expression patterns within the cells governing these biorhythms did not require any external, or extracellular, signals to continue ticking. In experiments described here, Michael Rosbash and his colleagues show that the key brain clock cells in fruit flies, called ventral lateral neurons, do indeed support the fly's circadian rhythms during periods of constant darkness, and that the molecular expression patterns associated with these rhythms continue to cycle as well within other clock cells. These sustained expression patterns, however, require intercellular communication between different groups of brain clock cells.

In other words, the ventral lateral neurons do not act alone. When the molecular clock machinery was manipulated so that only the ventral lat
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Contact: Barbara Cohen
bcohen@plos.org
415-624-1206
Public Library of Science
15-Sep-2003


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