HOME >> BIOLOGY >> NEWS
Cooperative action of two proteins causes damaged cells to "self-destruct"

REHOVOT, Israel -- December 20, 1999 -- Researchers at the Weizmann Institute of Science have recently deciphered part of the cellular events underlying apoptosis - programmed cell death. Their findings, published in Nature earlier this summer, provide important insights into cancer pathologies and their potential cures.

It is known that all cells contain a built-in suicide mechanism. This process is vital to normal embryonic development and tissue maintenance. It is the body's means of ridding itself of damaged or surplus cells.

Failure of the apoptosis or suicide mechanism can be deadly. Cell mutations occur regularly in every organism due to environmental factors, such as ultraviolet radiation and chemical toxins, as well as natural cell processes. If left unchecked, the damaged cells will continue to proliferate, often leading to life-threatening diseases, such as cancer.

This "emergency" suicide pathway is designed to reverse or mitigate mutation induced damage, explains Prof. Yosef Shaul of Weizmann's Molecular Genetics Department. It is an intricate check and balance system controlled by a tightly orchestrated team of genes and their respective proteins. These genes interact with each other in an environment characteristic of computer programming, where they respond to If, Then, Else signals concerning cellular functioning. The protein products of these genes will initially attempt to repair the damaged DNA. If they are unsuccessful, they command the cell to "self-destruct." In the third, and worst case scenario, both DNA repair and apoptosis fail, and the result is usually the growth of a tumor.

Yet who are these protein "players", and most importantly, how do they interact? This is what Shaul and colleagues, Prof. Moshe Oren, and Drs. Reuven Agami and Giovanni Blandino, set out to understand.

They began with c-Abl - a major regulator of cell growth which, when mutated, can act as an oncogene - a gene that causes cancer. E
'"/>

Contact: Jeffrey J. Sussman, Assist. V.P., Communications
jeffrey@acwis.org
212-779-2500 ext.121
American Committee for the Weizmann Institute of Science
19-Dec-1999


Page: 1 2 3

Related biology news :

1. Virginia Tech and North Carolina State University to run Forest Nutrition Research Cooperative
2. Rural Residents Cooperative Response To Water Crisis Now A Model
3. DNA lends scientists a hand, revealing new chemical reactions
4. Charting the future in prostate cancer care: A call to action
5. Defensive action by influenza viruses demonstrated by Hebrew university researcher
6. Long-term effects of carbon monoxide poisoning are an autoimmune reaction
7. Common call for action on European Research Council (ERC)
8. New technique helps scientists reveal interactions between genes and drugs
9. Rutgers cancer prevention expert calls for FDA action to reduce colon cancer and osteoporosis
10. Rutgers chemist uses NMR to elucidate protein-DNA interaction
11. Findings suggest need for new view of p53 cancer proteins interaction with DNA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... services, today announced that the company has received ISO9001:2015 certification for the ... and research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of large ... (LBA) have dominated this area. However, the use of mass spectrometry in this field ... necessitates the question “How do you choose which approach to use (LBA or MS)?” ...
(Date:6/23/2020)... , ... June 23, 2020 , ... In its June ... interview with Dr. James L. Sherley, M.D., Ph.D., founder and director of stem ... company announced on June 16 that starting July 5 it would begin ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/7/2020)... ... 06, 2020 , ... Bio-IT World has announced the winners ... the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance ... highlighting outstanding examples of how technology innovations and strategic initiatives can be powerful ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... access to competitively procured purchasing contracts to its membership, recently named BioFit ... TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a ... Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with ... , A Safe Space™ enabled business will provide a health performance index system that ...
Breaking Biology Technology:
Cached News: