HOME >> BIOLOGY >> NEWS
Coordinating power of circadian rhythms keeps estrus and pregnancy on track

In work reported this week, researchers at Northwestern University have begun to uncover the basis for how the daily patterns of biological behavior known as circadian rhythms are able to control complex events such as reproduction, which in female mammals requires precise but dynamic regulation of hormone levels.

Many biological processes, including sleep and wakefulness as well as feeding and metabolism, have a 24-hour rhythmicity. The circadian rhythms that underlie these patterns are controlled in the brain by a molecular clock that has a period of approximately 24 hours. By studying the Clock mutant mouse, which has a mutation in a gene that regulates the internal clock, researchers have shown that normal female reproductive function depends on an intact biological clock.

It had previously been known that removal of the part of the brain responsible for circadian behavior resulted in abnormal reproduction. In the new work, Howard Hughes Medical Institute investigator Dr. Joseph S. Takahashi, Northwestern University professor Dr. Teresa H. Horton, and graduate student Brooke H. Miller found that the disruption of the Clock gene resulted in abnormal estrous cycles (the mouse equivalent of human menstrual cycles), primarily due to a defect in the control of hormone release by the brain. The researchers also found that Clock mutant females exhibited high rates of mid-gestation pregnancy failure, a process that had not previously been linked to circadian rhythms.

These experiments increase the understanding of the way complex physiology can be regulated by circadian rhythms. More broadly, the findings have implications for human infertility; it has been shown that women who work swing-shifts are more susceptible than normal to irregular menstrual cycles and miscarriage.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
9-Aug-2004


Page: 1

Related biology news :

1. Green, leafy spinach may soon power cellphones and laptops
2. Wastewater could treat itself, power city
3. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
4. FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
5. Spanish scientists develop powerful tool for exploration and integration of biological information
6. Volcanic soils yield new clues about the emergence of powerful chiefdoms in Hawaii
7. Motion that powers sperm provides key to unravelling rare genetic disorder
8. Ethanol to power the future of hydrogen fuel cells
9. A shocking surprise: High voltage + rats = ozone, reopens power-line debate
10. Work begins on powering a sustainable future for the UK
11. Fruits offer powerful protection from skin cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... March 23, 2017 The report "Gesture Recognition and Touchless ... and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is ... of 29.63% between 2017 and 2022. Continue Reading ... ... ...
(Date:3/20/2017)... , March 20, 2017 At this year,s ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand ... is this year,s CeBIT partner country. At the largest German biometrics ... in use: fingerprint, face and iris recognition as well as DERMALOGĀ“s multi-biometrics ... ...
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, ... Simple," and 23andMe , the leading personal genetics ... choices.  Zipongo can now provide customers with personalized nutrition ... goals and biometrics, but also genetic markers impacting how ... Zipongo,s personalized food decision support platform uses biometrics ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... 23, 2017 In today,s pre-market ... in the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), ... MKT: SYN), and Regulus Therapeutics Inc. (NASDAQ: ... Credit Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." ... report at: ...
(Date:3/22/2017)... ... March 22, 2017 , ... Researchers ... from small lab samples to full-size tissues, bones, even whole organs to implant ... system that delivers blood deep into the developing tissue. , Current bioengineering ...
(Date:3/22/2017)... -- Good Start Genetics, a leading family genomics company, ... covered lives mark through its most recent payor addition, ... . With newly signed contracts nationally and others in ... acceptance based on the quality of its science, the ... industry-leading customer care and support and its published cost-effectiveness ...
(Date:3/22/2017)... The global chronic kidney disease ... by Transparency Market Research (TMR). The top four players, ... Inc., accounted for a share of only 41.4% in ... market are focusing aggressively on mergers, acquisitions, and strategic ... to lead to market consolidation in the next few ...
Breaking Biology Technology:
Cached News: