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Copper chelation is a promising new therapy for clogged arteries

ssue responsible for narrowing of the arteries. TTM was able to inhibit the intracellular function of key regulators of cell growth which normally enable cells to respond to stress. Essentially, chelating copper makes the cells stress resistant.

Understanding the biochemical pathways of cellular response to stress or injury may lead to an alternative and inexpensive treatment to efficiently manage restenosis in humans.

The discovery is the result of approximately fifteen years of basic scientific research. The researchers found that an easily obtained chemical reagent made a direct and simple clinical application suddenly available. The drug TTM is already in use for the treatment of another human disease and, interestingly, has very few and readily reversible side effects.


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Contact: Wayne L. Clark
clarkw@mmc.org
207-871-2196
Maine Medical Center
22-May-2003


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