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Corvas presents 3-D molecular structure of matriptase, first structural insight into new class of protease cancer targets

coupled with Corvas medicinal chemistry expertise in the design and synthesis of proprietary small molecule inhibitors of serine proteases provides a comprehensive discovery platform that the Company believes will accelerate the development of novel therapeutic approaches to solid tumor cancers.

Corvas expertise in protease modulation has been developed in conjunction with the Companys cardiovascular (thrombosis or blood clotting) and infectious disease (hepatitis C virus infection) programs that are based on synthetic small molecule inhibitors of serine proteases. Corvas has an active medicinal chemistry based program in the design of inhibitors to urokinase plasminogen activator (u-PA). u-PA is a serine protease that has been implicated in the growth and progression of certain solid tumor cancers such as breast cancer. Highly selective and potent small molecule lead inhibitors of u-PA have been shown to inhibit angiogenesis and tumor growth in animal models. The Company has identified more than 70 cancer-associated proteases and has filed patents on several full-length gene sequences including high throughput screening methods for the respective proteases.


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Contact: Virginia Amann
vamann@irpr.com
858-860-0266
Atikins + Associates
27-Aug-2001


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