ies, and one in five pregnancies end in miscarriage, many second and third miscarriages are likely to be simply by chance alone. In addition, other studies have shown that these couples have a 70 percent chance of having a successful subsequent pregnancy," said Dr. Hogge. "If there is a chromosomal abnormality, there's no reason to do more extensive and expensive testing."

Dr. Hogge and his colleagues recommend that karyotyping tests be pursued regularly after the second loss, with more advanced diagnostic tests ordered for both parents only when no genetic abnormality is found. "Having an explanation for the loss often removes significant guilt regarding whether the couple 'did something wrong to cause the miscarriage,' " he said.

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Contact: Michele Baum
412-647-3555
University of Pittsburgh Medical Center
27-Jan-2003

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