The aesthetic qualities of obesity are the least of the problems associated with this spike in worldwide weight gain. The disorder is associated with an increased risk of life threatening conditions such as diabetes, hypertension and heart diseases, and weight loss has been reported to ameliorate these associated conditions. To prevent these chronic disorders, some try to reduce weight by caloric restriction; however the effort generally fails as most obese patients regain their lost weight thereafter.
Therefore, medicinal treatment becomes a necessity. One facet currently being explored is the central regulators of food intake. This includes the cannabinoid system with its putative endogenous ligands anandamide and 2-arachidonoyl glycerol (2-AG). In addition to its many pharmacological activities, this system has been implicated in food intake regulation.
Stimulation of appetite is one of the most commonly related effects of marijuana in humans and delta-9-tetrahydrocannabinol (-9-THC), the main active component of this drug, has been reported to produce hyperphagia. The endogenous cannabinoids anandamide and 2-AG also s
Contact: Donna Krupa
American Physiological Society