HOME >> BIOLOGY >> NEWS
Could hibernators hold the key to improving organ preservation?

m cold storage followed by warm reperfusion. Studies by other scientists have shown that this can lead to the release of potentially damaging chemicals, such as reactive oxygen species and pro-inflammatory cytokines that can produce oxidative stress. In contrast, there is little evidence of activation of Kupffer cells in hibernator livers after long-term cold storage, an effect that should reduce liver damage. Hibernator livers also maintain gluthathione redox balance to a better degree than do rats with increasing cold storage time. Because glutathione is an antioxidant, this is another mechanism by which hibernator organs may be protected from cold ischemia/reperfusion injury.

  • A transcription factor, NF-kB, which can initiate pro-inflammatory pathways and has been implicated in liver injury after cold storage/reperfusion, is activated in rat livers. This occurs after 24 hours of cold storage in rat livers, but it is not activated in livers of hibernators.

  • Hibernators have much higher levels of a protective protein (known as HSP70) in their livers than do rats. HSP70 has been shown in other studies to confer protection to tissues and organs when they are stressed, such as after cold storage and reperfusion.

    Conclusions

    Taken together, the current and earlier studies provide exciting new directions that will help researchers identify the specific mechanisms that hibernators use to avoid tissue and organ damage during the highly altered physiology that accompanies hibernation. By fully understanding these mechanisms, these researchers believe that therapeutic advances can be developed which will protect human organs during trauma states and organ transplantation.


    '"/>



  • Contact: Donna Krupa
    djkrupa1@aol.com
    703-967-2751
    American Physiological Society
    9-Apr-2003


    Page: 1 2 3

    Related biology news :

    1. Endometriosis: Could angiostatic therapy be the new treatment of the future?
    2. Could mice hold the secret to longer life?
    3. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
    4. Could memory performance and spatial learning be genetically based?
    5. Could a specific protein contribute to erectile dysfunction for the diabetic and obese?
    6. Could diabetes treatments fight cancer?
    7. Could rice be the source for a natural herbicide?
    8. Could Bt transgenic crops have nutritionally favourable effects on insects?
    9. Could one less cookie a day help the fight against fat?
    10. Could an anti-marijuana compound hold the key to body weight and appetite control?
    11. Study finds genetic aberrations linked to lung cancer; Could help in early diagnosis

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
    (Date:6/23/2020)... ... June 23, 2020 , ... ... to announce the next event in a series of TOPIQ webinars, which will ... series of webinars was developed in response to social distancing measures that resulted ...
    (Date:6/13/2020)... Va. (PRWEB) , ... June 11, 2020 , ... ... forensic DNA services, announces a significant expansion of its forensic genealogy team. ... enforcement and attorneys through proven forensic genealogy and DNA analysis methods. The team ...
    Breaking Biology News(10 mins):
    (Date:6/23/2020)... ... 2020 , ... Regen Suppliers, the one stop shop for ... get the fourth unit free with no limit on the amniotic derived exosomes. ... have been a game changer for regenerative therapies. The products are manufactured at ...
    (Date:6/19/2020)... ... June 18, 2020 , ... The Vitaspace project was founded ... forces to radically prolong life and find a way (medicine or technology) that will ... was supported by various scientists from all over the world, doctors, and all people ...
    (Date:6/11/2020)... (PRWEB) , ... June 09, 2020 , ... ... the release of the NEON Micro-Tracer Solution, a highly accurate, contact ... COVID-19 virus in the workplace. Contact tracing, a core disease control measure, is ...
    (Date:6/2/2020)... ... June 01, 2020 , ... As part of its ongoing ... the world, enterprise security solutions provider bitsIO donated time to help two companies ... during self-quarantines and shelter-in-place orders, companies are increasingly concerned about the security of ...
    Breaking Biology Technology:
    Cached News: