February 4, 2004 BETHESDA, MD As the US population ages, there is an increasing effort to understand the underlying mechanisms that contribute to learning and memory. This effort could be of critical importance to scientists trying to decipher how the molecular genetic mechanisms of learning and memory are disrupted or impaired. The results of a new study provide evidence that individual differences in some cognitive functions may have a genetic basis.
A New Study
The authors of the study are Nelson Ruiz-Opazo, of the Section of Molecular Medicine, Boston University School of Medicine, Boston, MA, and John Tonkiss, from the Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, Boston, MA. Their study, entitled "X-Linked Loci Influence Spatial Navigation Performance in Dahl Rats," now appears in the Articles in Press section of Physiological Genomics, one of one of 14 scientific journals published monthly by the American Physiological Society (APS) (www.the-aps.org).
Methodology
Dahl S/hsd (n=12) and Dahl R/hsd (n=12) male rats were obtained. Reciprocal mating of the parental strains (Dahl R female x Dahl S male and Dahl S female x Dahl R male) produced two types of F1 male hybrids: F1[RXS] (n=12) and F1[SXR] (n=11), respectively. A cohort was derived from brother-to-sister mating of F1 (R female x S male) hybrids to produce and F2 male segregation population (n=178). Behavioral testing was performed on parental, F1 and F2 cohorts at 12 weeks of age.
The Morris water maze (MWM) task was performed using a circular water maze and a computer tracking system. A circular platform was placed at the center of one of four imaginary quadrants and the water rendered opaque. Swim distance was used to evaluate performance.
In the hidden platform version of the maze task the platform was submerged below the water's surface and
'"/>Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society 4-Feb-2004Page: 1 2 3 Related biology news :1.
Endometriosis: Could angiostatic therapy be the new treatment of the future?2.
Could mice hold the secret to longer life?3.
Could vitamins raise levels of bad cholesterol? Animal study suggests they might4.
Could a specific protein contribute to erectile dysfunction for the diabetic and obese?5.
Could diabetes treatments fight cancer?6.
Could rice be the source for a natural herbicide?7.
Could hibernators hold the key to improving organ preservation?8.
Could Bt transgenic crops have nutritionally favourable effects on insects?9.
Could one less cookie a day help the fight against fat?10.
Could an anti-marijuana compound hold the key to body weight and appetite control?11.
Study finds genetic aberrations linked to lung cancer; Could help in early diagnosis