A New Study
The authors of the study are Nelson Ruiz-Opazo, of the Section of Molecular Medicine, Boston University School of Medicine, Boston, MA, and John Tonkiss, from the Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, Boston, MA. Their study, entitled "X-Linked Loci Influence Spatial Navigation Performance in Dahl Rats," now appears in the Articles in Press section of Physiological Genomics, one of one of 14 scientific journals published monthly by the American Physiological Society (APS) (www.the-aps.org).
Dahl S/hsd (n=12) and Dahl R/hsd (n=12) male rats were obtained. Reciprocal mating of the parental strains (Dahl R female x Dahl S male and Dahl S female x Dahl R male) produced two types of F1 male hybrids: F1[RXS] (n=12) and F1[SXR] (n=11), respectively. A cohort was derived from brother-to-sister mating of F1 (R female x S male) hybrids to produce and F2 male segregation population (n=178). Behavioral testing was performed on parental, F1 and F2 cohorts at 12 weeks of age.
The Morris water maze (MWM) task was performed using a circular water maze and a computer tracking system. A circular platform was placed at the center of one of four imaginary quadrants and the water rendered opaque. Swim distance was used to evaluate performance.