Could vitamins raise levels of bad cholesterol? Animal study suggests they might

ggested that antioxidant vitamins prevented biochemical changes that made cholesterol form plaques that can block blood flow through the arteries. Although some subsequent clinical studies seemed to back up these findings, others did not.

The new study by Dr. Fisher and his colleagues provides a different perspective on antioxidants. Surprisingly, his group found that antioxidants hampered a process in the liver that prevents the production of harmful lipoproteins.

When cells are under "oxidative stress," free radicals produced by the normal conversion of polyunsaturated fatty acids to lipid peroxides bombard the cells. The scientists discovered that liver cells respond by activating a pathway that breaks down ApoB100, a critical protein component of VLDL and other harmful lipoproteins. Deprived of the ApoB, the liver cannot now produce these bad lipoproteins and their secretion into the bloodstream is reduced substantially.

In further experiments, vitamin E, a well-known antioxidant, prevented the activation of the lipoprotein-breakdown pathway in rat and mouse liver cells. Thus, the liver destroyed fewer of the bad lipoproteins.

The study also explains why polyunsaturated fatty acids, the good fatty acids found in cold water fish, are healthy for the heart. In another series of experiments, the scientists show that omega-3 and omega-6 fatty acids activated the pathway in the liver that breaks down the bad lipoproteins. Dr. Fisher's group recently described this pathway, which they dubbed PERPP for post-ER presecretory proteolysis.

The scientists also found that the polyunsaturated fatty acids increased the generation of lipid peroxidation products (these compounds produce the nasty smell of rancid fish) and stimulated the PERPP pathway. In addition to the studies with liver cells in laboratory dishes, they also demonstrated the relationship between lipid peroxidation and reduced production of

Contact: Jennifer Berman
New York University Medical Center and School of Medicine

Page: 1 2 3 4

Related biology news :

1. Endometriosis: Could angiostatic therapy be the new treatment of the future?
2. Could mice hold the secret to longer life?
3. Could memory performance and spatial learning be genetically based?
4. Could a specific protein contribute to erectile dysfunction for the diabetic and obese?
5. Could diabetes treatments fight cancer?
6. Could rice be the source for a natural herbicide?
7. Could hibernators hold the key to improving organ preservation?
8. Could Bt transgenic crops have nutritionally favourable effects on insects?
9. Could one less cookie a day help the fight against fat?
10. Could an anti-marijuana compound hold the key to body weight and appetite control?
11. Study finds genetic aberrations linked to lung cancer; Could help in early diagnosis

Post Your Comments:

(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... to participate in the prestigious National STEM Scholar Program, a unique professional development ... building, and project support for middle school science teachers nationwide. , Created in ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... for the life sciences industry, today announced the release of its signature ... for Medical Science Liaisons (MSLs) and other field medical professionals. , ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter maintenance ... a successful study, while protecting and accessing the catheter or device post-surgery is often ... Envigo in a live webinar on Wednesday, August 5, 2020 ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign , ... and prevention of high-burden diseases, and Centric Consulting, a business and technology consulting ... utilize existing data in order to identify and prioritize patients for care. , ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode ... significant expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . ... , Bode-CARES provides a turnkey solution that includes a comprehensive ...
Breaking Biology Technology:
Cached News: