HOME >> BIOLOGY >> NEWS
Counting the cost of genome projects

What price knowledge? In the opinion of scientists, at least, the expense of sequencing genomes will be more than offset by the medical and scientific gains to follow. Taxpayers, however, surely hope the cost of these gains remains reasonable. Now, in this month's issue of Genome Research, a team led by Eric Lander of the Whitehead Institute for Biomedical Research analyzes the efficiency of current sequencing approaches and proposes a strategy to slash the price tag on genome projects.

Deciphering the typical mammalian genome requires scientists to break up its millions of DNA base pairs into manageable fragments, sequence the pieces, and (the tricky part) somehow assemble them back together. In an approach called "walking," researchers reassemble the genome by first sequencing a random selection of the genome fragments. They then search for fragments that partially overlap with these finished pieces, sequence the new fragments, and so on. The scientists can thus sequence sizeable segments of the genome in orderly procession, finishing when all the segments meet.

Where does excess cost arise? Making the segments meet involves sequencing some parts of the genome twice, a necessary evil that balloons the final tab. By constructing a mathematical model of the walking process, Lander and colleagues determine several methods to reduce this obligatory "redundant sequencing." The strategies they propose may substantially decrease the cost of sequencing enterprises, including the billion-dollar Human Genome Project.


'"/>

Contact: Peggy Calicchia
calicchi@cshl.org
516-367-6834
Cold Spring Harbor Laboratory
27-Dec-1999


Page: 1

Related biology news :

1. Counting foxes before the last tally-ho
2. Counting the molecules that pull cells apart
3. Counting the molecules that pull cells apart
4. Counting semi-viable bacteria in cheese
5. Counting salmon essential measure of recovery efforts
6. Counting elephants by monitoring sounds
7. Counting X Chromosomes To Determine Sex
8. Detecting Deer: New Method For Counting Population In Urban Areas
9. Scientists sequence genome of kind of organism central to biospheres carbon cycle
10. Keep genome data freely accessible
11. The book opens on the first tree genome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... BOSTON (PRWEB) , ... January 10, 2019 , ... When ... company Asymmetrex , was invited to contribute a chapter to the new book ... “I wanted to continue Asymmetrex’s effort to address a debilitating secret of stem cell ...
(Date:1/8/2019)... ... January 07, 2019 , ... ... is proud to welcome Thomas Kennedy as head of sales and business development ... PureWay. , Mr. Kennedy has previously worked for Johnson & Johnson Medical, Globus ...
(Date:1/7/2019)... ... 07, 2019 , ... Franz Inc. , an early ... Knowledge Graphs solutions, announced that it was recognized by Database Trends and ... and information management recognition list includes newer approaches leveraging artificial intelligence, machine learning, ...
Breaking Biology News(10 mins):
(Date:12/20/2018)... (PRWEB) , ... December 20, 2018 , ... New Year’s ... with major changes in regulations in the European Union (EU) on the horizon, Jim ... to consider. , “The transition to the EU Medical Device Regulation (MDR), digital health, ...
(Date:12/18/2018)... , ... December 18, 2018 , ... ... process optimization firm for the life sciences industry, unveiled a completely redesigned website ... creating a more user-friendly browsing experience for their valued clients and business partners. ...
(Date:12/13/2018)... ... December 12, 2018 , ... RURO, ... solutions, announces the Limfinity® ML (Machine Learning) addition for its Limfinity® 7 framework. ... within Limfinity® solutions. In the module, trained models make predictions based on user ...
(Date:12/5/2018)... ... December 05, 2018 , ... Leading authority on how to bridge the gap ... “The Referral Playbook: How to Increase Sales with Proven Networking Strategies.” ... to the Alzheimer’s Foundation of America (AFA). , Itzkowich is hosting “The Referral ...
Breaking Biology Technology:
Cached News: