HOME >> BIOLOGY >> NEWS
'Cousin' Of Snake Venom Toxin Found In Mice

ily to which the gene belonged. "Nat and I sat down at the computer one day and tried to match lynx1's sequence of amino acids with those of known proteins. We did an exhaustive search of the database utilizing several different algorithms, then suddenly we got a hit," Miwa said. Relatively small but critically important sections within lynx1 matched the amino acid sequence of a snake toxin called alpha-bungarotoxin. This venom is a member of a large family of proteins called Ly-6. With that in mind, Heintz and Miwa named their gene "lynx," for Ly-6 neurotoxin.

"At that point we realized the potential significance of lynx1," Miwa said. "Bungarotoxin was known to bind to acetylcholine receptors, so if lynx1 could bind to these receptors too, it might be important for brain signaling."

Ines Ibanez-Tallon, an HHMI associate in Heintz's lab, localized the nerve cell receptors with which lynx1 interacts, and showed that the distribution of these receptors is similar to that of acetylcholine receptors in the cerebellum, a region of the brain involved in controlling motion and motor learning.

Additional collaborators in Lorna Role's laboratory at Columbia University tested lynx1's effect on frog eggs (or oocytes) that had been injected with acetylcholine receptors. Miwa said the eggs' acetylcholine response was 30 percent larger after bathing them with lynx1, suggesting that lynx1 might enhance the action of acetylcholine. By contrast, its cousin, alpha-bungarotoxin, interferes with acetylcholine's activity. But many drugs that affect the brain have been found to generate effects opposite to those of similar substances produced by brain tissue, Heintz said.

Acetylcholine receptors are thought to be involved in memory and in the pathogenesis of Alzheimer's disease, where loss of inputs from acetylcholine neurons is a hallmark of the disease. "If lynx1 acts in the whole animal like it does in cells, then the structure of the p
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-May-1999


Page: 1 2 3

Related biology news :

1. Snakehead in your inbox? Welcome to the nonindigenous Aquatic Species Alert System
2. Controlling Problem Snakes: Saipan Benefits From USGS Research
3. A Real Smart Asp: Snakes Show Surprising Ability To Learn
4. Experimental Drug Derived From Snake Venom Shows Promise In Reversing Effects Of Stroke
5. Snake Venom Slows Tumor Growth
6. Venom hunt finds harmless snakes a potential danger
7. Venomous dinosaurs really existed
8. Spider Venom Stops Stroke Brain Damage
9. Salve From Serpents? UD Studies May Explain Why Viper-Venom Protein Stops Tumor Spread In Mice
10. Toxin combo common in fish appears capable of impairing motor skills
11. Symposium Probes Impact Of Toxins On Development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... -- PMD Healthcare announces the release of its new ... (WMS), a remote, real-time lung health monitoring and management ... a Medical Device, Digital Health, and Chronic Care Management ... solutions that empower people to improve their healthcare and ... the first ever personal spirometer, Spiro PD, which was ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
Breaking Biology News(10 mins):
(Date:3/20/2017)... , ... March 20, 2017 , ... ... HEPARIN calibration verification / linearity test kit has received US FDA 510(k) clearance ... VALIDATE® HEPARIN kit evaluates Heparin Anti-Xa activity in a human plasma matrix. ...
(Date:3/20/2017)... NEW YORK , March 20, 2017  Attorney Advertising ... behalf of purchasers of the BioAmber Inc. ("BioAmber" or the "Company") ... obtain additional information and assist the investigation by visiting the ... concerns whether BioAmber and certain of its officers and/or directors ... Act of 1934. ...
(Date:3/19/2017)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Food and Drug Administration,s (FDA) Division of Oncology Products ... for the treatment of NRAS -mutant melanoma, a ... This action was based on thorough discussions and communications ... approval, and followed the late cycle review meeting held ...
(Date:3/18/2017)... , March 17, 2017  A new study ... who historically have been considered ineligible for curative ... reirradiation using intensity-modulated proton therapy (IMPT) for lung ... patients were free from local recurrence at one ... ten patients experienced severe side effects. The study ...
Breaking Biology Technology:
Cached News: