HOME >> BIOLOGY >> NEWS
'Cousin' Of Snake Venom Toxin Found In Mice

ily to which the gene belonged. "Nat and I sat down at the computer one day and tried to match lynx1's sequence of amino acids with those of known proteins. We did an exhaustive search of the database utilizing several different algorithms, then suddenly we got a hit," Miwa said. Relatively small but critically important sections within lynx1 matched the amino acid sequence of a snake toxin called alpha-bungarotoxin. This venom is a member of a large family of proteins called Ly-6. With that in mind, Heintz and Miwa named their gene "lynx," for Ly-6 neurotoxin.

"At that point we realized the potential significance of lynx1," Miwa said. "Bungarotoxin was known to bind to acetylcholine receptors, so if lynx1 could bind to these receptors too, it might be important for brain signaling."

Ines Ibanez-Tallon, an HHMI associate in Heintz's lab, localized the nerve cell receptors with which lynx1 interacts, and showed that the distribution of these receptors is similar to that of acetylcholine receptors in the cerebellum, a region of the brain involved in controlling motion and motor learning.

Additional collaborators in Lorna Role's laboratory at Columbia University tested lynx1's effect on frog eggs (or oocytes) that had been injected with acetylcholine receptors. Miwa said the eggs' acetylcholine response was 30 percent larger after bathing them with lynx1, suggesting that lynx1 might enhance the action of acetylcholine. By contrast, its cousin, alpha-bungarotoxin, interferes with acetylcholine's activity. But many drugs that affect the brain have been found to generate effects opposite to those of similar substances produced by brain tissue, Heintz said.

Acetylcholine receptors are thought to be involved in memory and in the pathogenesis of Alzheimer's disease, where loss of inputs from acetylcholine neurons is a hallmark of the disease. "If lynx1 acts in the whole animal like it does in cells, then the structure of the p
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-May-1999


Page: 1 2 3

Related biology news :

1. Snakehead in your inbox? Welcome to the nonindigenous Aquatic Species Alert System
2. Controlling Problem Snakes: Saipan Benefits From USGS Research
3. A Real Smart Asp: Snakes Show Surprising Ability To Learn
4. Experimental Drug Derived From Snake Venom Shows Promise In Reversing Effects Of Stroke
5. Snake Venom Slows Tumor Growth
6. Venom hunt finds harmless snakes a potential danger
7. Venomous dinosaurs really existed
8. Spider Venom Stops Stroke Brain Damage
9. Salve From Serpents? UD Studies May Explain Why Viper-Venom Protein Stops Tumor Spread In Mice
10. Toxin combo common in fish appears capable of impairing motor skills
11. Symposium Probes Impact Of Toxins On Development

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cousin Snake Venom Toxin Found Mice

(Date:7/28/2014)... Roald Amundsen reached the South Pole in 1911, but ... before any human. , Using data from 16 ice ... continent, including the South Pole, a group led by ... Reno, Nevada, created the most accurate and precise reconstruction ... The new record, described in an article published today ...
(Date:7/28/2014)... of people in the United States have a circulatory ... can be painful and may even require surgery in ... muscle wasting and, in turn, limb amputation. , At ... (UTHealth) Medical School, scientists tested a non-surgical preventative treatment ... was associated with increased blood circulation. Their proof-of-concept ...
(Date:7/28/2014)... -- Fifteen years ago, MIT professor John Essigmann and colleagues ... an HIV drug. They thought if they could induce the ... and eventually die out a strategy that our immune ... such a drug, which caused HIV to mutate at an ... virus from patients in a small clinical trial reported in ...
Breaking Biology News(10 mins):Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4
(Date:7/29/2014)... The prestigious "Discovery or Exploration in History Award" ... Juliana Hillis and Kaylie O’Connell, students at Stoneham High ... Egg, Everything: America’s First IVF Baby". This project was ... History Day program during a week-long final competition judged ... D.C. , The growing popularity of the assisted reproductive ...
(Date:7/29/2014)... CA (PRWEB) July 29, 2014 ... medical devices, and cloud based eClinical technologies, have been ... Device Online. These follow a long line of white ... profile publications including Life Science Leader, Pharmaceutical Online, and ... Clinovo provided a paper by CTO Marc Desgrousilliers, ...
(Date:7/29/2014)... 2014 PlaqueTec ... Erfassung biologischer Daten in Verbindung mit Herzerkrankungen ... Das LBS nimmt gleichzeitig mehrere Blutproben von ... und sucht erhöhte biologische Aktivitäten in erkrankten ... Entdeckung und Entwicklung neuer Medikamente und Therapeutika ...
(Date:7/28/2014)... Sapphire Energy, Inc. , a global ... of biotechnology veteran James Levine as president, ... replaces Cynthia ,CJ, Warner, who is stepping down from ... the company,s board of directors. "The impact ... commercial scale algae-based fuels has been tremendous, from overseeing ...
Breaking Biology Technology:In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 2PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 4Sapphire Energy Announces New CEO James Levine 2Sapphire Energy Announces New CEO James Levine 3
Cached News: