HOME >> BIOLOGY >> NEWS
Cox-2 enzyme plays important role regulating acute pancreatitis and associated lung injury

(December 17, 2002) Bethesda, MD Clinical acute pancreatitis can present with varying degrees of severity The chief causes of this disorder are gallstones, gallbladder-related disease and alcohol use. Viral infection, mumps, and certain medications such as corticosteroids, diuretics, and tetracycline are other causes. In adults, the disorder is frequently associated with lung injury, manifesting itself as adult respiratory distress syndrome.

Background

While the catalyst for pancreatitis is not well known, it is thought that enzymes normally secreted by the pancreas in an inactive form become activated inside the pancreas and start to digest the pancreatic tissue. This process is called autodigestion and causes swelling, hemorrhage, and damage to the blood vessels. An attack may last for 48 hours, and damage to the Cyclooxygenase-2 (COX-2), a widely distributed enzyme, plays an important role in pancreatic inflammation.

The initiation of prostanoid synthesis from arachidonic acid involves the enzyme cyclooxygenase (COX), an enzyme that is also referred to as PGH synthase or PG endoperoxide synthase, because it is also the rate limiting enzyme for PGE2 synthesis.

Two COX isoforms have been identified; first, as a constitutive form (COX-1), which is thought to have an important housekeeping function; and second, as an inducible form (COX-2), which has been implicated as an important pro-inflammatory mediator. COX-2 is up-regulated in response to a variety of pro-inflammatory stimuli including IL-1, TNF, and bacterial lipopolysaccharide. COX-2 mRNA and protein levels are increased during experimental pancreatitis, but the role of COX-2 in pancreatitis has heretofore not been well defined.

The Study

A new study has explored the role of COX-2 in acute pancreatitis and pancreatitis-associated lung injury. The protocols entailed pretreating selected mice with COX-2 inhibitors, whereas other mice were bred with gen
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
17-Dec-2002


Page: 1 2 3

Related biology news :

1. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
2. First glimpse of DNA binding to viral enzyme
3. Two enzymes key to calorie-burning, Brown research shows
4. Argonne scientists determine structure of staph, anthrax enzyme
5. Brain serotonin enzyme finding might explain psychiatric disorders
6. Study finds plant enzyme function changes with location in cell
7. Basic RNA enzyme research promises single-molecule biosensors
8. Molecule that blocks key bacterial enzyme may lead to new antibiotics
9. Study finds first evidence COX-2 enzymes can regulate DNA damage
10. UNC scientists block cellular enzyme activity involved in cancer progression
11. ADAM: Good enzyme for Alzheimer disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... 2019 , ... In’Tech Medical SAS ( http://www.intech-medical.com ), the ... $31M, up 12% from Q1-18. The growth is associated with uptick in activity ... initiatives worldwide. , Laurent Pruvost , President & CEO of In'Tech Medical, ...
(Date:6/4/2019)... ... 2019 , ... Lajollacooks4u is delighted to announce it has been named as ... is given only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, ... , To qualify for the Certificate of Excellence –- an award that only 10 ...
(Date:5/31/2019)... Calif. (PRWEB) , ... May 30, 2019 , ... ... clinical genetics testing company, and Mayo Clinic, have documented significant differences in the ... among racial and ethnic populations compared to non-Hispanic White women. Results will be ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... ... 2019 , ... Today, at the BIO World Congress on Industrial ... (NCGA) announced the winners of the Consider Corn Challenge II. Three winners were chosen, ... to produce biobased materials. , “Corn is a sustainable, abundant and affordable ...
(Date:6/26/2019)... VEGAS (PRWEB) , ... June 26, 2019 , ... Alice ... energy treatment on improving physicochemical properties of Magnesium Gluconate, which can prove to be ... Over 125% alteration of characteristic differentiation peak, change in crystallite size , ...
(Date:6/12/2019)... ... June 12, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, ... been signed. The agreement will grant exclusive rights for Zillion to represent LDA ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve ... of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. , ... library of more than 20 million articles, sourced from more than 15,000 journals. ...
Breaking Biology Technology:
Cached News: