Critical therapeutics is awarded U.S. patents for methods to diagnose and treat inflammatory disease

Cambridge, Massachusetts, December 2, 2002 -- Critical Therapeutics, Inc. (CTI) today announced that it has been awarded three U.S. patents covering methods to diagnose, predict the severity of and treat serious inflammatory diseases including sepsis, a bloodstream infection that is the nation's tenth leading cause of death.

The patents, which were issued by the United States Patent and Trademark Office, relate to a protein within the High Mobility Group (HMGB) family of nuclear proteins. This protein, HMGB1, has been identified as an important mediator of the body's inflammatory response to infection, ischemia and injury. Increased levels of HMGB1 have been implicated in sepsis and other major inflammatory diseases including rheumatoid arthritis.

"Therapies targeting HMGB1 can potentially afford significant benefits to critically ill patients stricken with serious systemic inflammatory disease," said Walter Newman, Ph.D., CTI's chief scientific officer. "As a result, these patents give CTI a strong intellectual property foothold as we move forward with discovery and development initiatives related to this protein."

U.S. patent number 6,468,533 B1, "Antagonists of HMGB1 for Treating Inflammatory Conditions," provides a pharmaceutical composition comprised of an antibody that binds HMGB1. The antibody, in turn, is believed to dramatically reduce the "cytokine cascade," or overproduction, of HMGB1 that triggers sepsis and other inflammatory diseases.

U.S. patent number 6,448,223 B1, "Antagonists of HMGB1 for Treating Inflammatory Conditions," covers a method of administering antibodies to treat the inflammatory illness. These antibodies neutralize the pro-inflammatory effect of HMGB1.

U.S. patent number 6,303,321 B1, "Methods of Diagnosing Sepsis," provides for a method to diagnose the disease and to predict its severity by measuring the concentration of HMGB1 in the serum.

The Society of Critical Care Medicine def

Contact: Scott Solomon
Sharon Merrill Associates, Inc.

Page: 1 2

Related biology news :

1. Critically endangered monkey species plummets more than 50 percent since 1994
2. Save The Tiger Fund announces alliance with the Critical Ecosystem Partnership Fund
3. Critical Therapeutics announces issuance of US patent for novel anti-inflammatory technology
4. Medimmune and Critical Therapeutics to co-develop treatments for severe inflammatory diseases
5. Critical Therapeutics launches Phase I clinical trial of anti-inflammatory compound
6. Critical early-defense trigger in plants found
7. Researchers, Regulators, Industry, Consumer Advocates Gather to Discuss Critical Issues Facing the Pharmaceutical Industry
8. Study Furthers Understanding Of Critical Alzheimers Disease Gene
9. Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm
10. UF Researchers: Gene Therapy Replaces Critical Protein In Animal Model Of Often-Fatal Lung-Liver Disease
11. Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say

Post Your Comments:

(Date:8/26/2020)... ... August 25, 2020 , ... Mitotech ... partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and Dermatology, ... of SkQ1 ophthalmic solution in patients with moderate to severe Dry Eye ...
(Date:8/21/2020)... (PRWEB) , ... August 19, 2020 , ... ... Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more than ... the recently published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva ...
(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, a ... announce that Eric Chen and Jessica Wong have joined the company’s leadership team ... respectively. , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, an ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... ... 5000 list, the most prestigious ranking of the nation’s fastest-growing private companies. The ... economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, ...
(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... DNA vaccine industries, announces it has closed on the purchase of greenfield for ... in Conroe, TX and includes over 21 acres in the initial acquisition, with ...
(Date:7/31/2020)... STATION, Texas (PRWEB) , ... July 29, 2020 ... ... cleanroom solutions today announced the launch of its new tagline, “BUILDING FOR LIFE.” ... the biopharmaceutical industry and around the globe, requiring fast track capacity to provide ...
(Date:7/31/2020)... ... 2020 , ... eSource has long been touted as the solution to high ... eSource, the reasons it did not take off as quickly as people initially expected, ... is moving towards capturing data electronically for clinical trials and then repurposing it for ...
Breaking Biology Technology:
Cached News: