witch's research is important for two reasons. Firstly, this novel method provides a generalizable framework within which gene expression in development and tumorigenesis can be studied. By this means, the role of a particular gene in tumor progression can be better understood. And secondly, since this analysis is readily applicable to other tumor types it can be developed as a useful tool for both tumor diagnosis and prognosis.

Indeed, the investigators show that similar findings are obtained when a human squamous cell lung cancer is compared with the developing rodent lung. "Much work remains to be done to determine whether the 'developmental perspective' can lead to clinically meaningful insights such as advances in diagnosis or our understanding of tumor behavior," Kohane said. "This study provides a foundation to ask these questions and facilitate translation of a large basic science knowledge base into the clinical sphere."

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Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
19-Mar-2004

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