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Crucial brain development gene identified

ered alongside what little is known about the human version of the Lgl1 gene: Human Lgl1 resides on the short arm of chromosome 17, in a region that is affected in half of all medulloblastoma brain tumors.

While further research is needed to delineate the role of Lgl1 in human brain cancer, Dr. Vasioukhin feels confident that "the morphologic and biochemical similarities between Lgl-/- and human primitive neuroectodermal tumors provide solid grounds for considering mammalian Lgl1 a candidate mammalian tumor-suppressor gene."


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Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
9-Mar-2004


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