HOME >> BIOLOGY >> NEWS
Crystal Structure Of The Archaeal Chaperonin Thermosome, A Protein-Folding Machine, Determined

A research team at the Max Planck Institute of Biochemistry , Martinsried/Germany, and the Institute of Microbiology, University of Regensburg, has solved the crystal structure of the thermosome. This structure, published in Cell on April 3, 1998, provides clues for understanding the mode of action of archaeal and eukaryotic chaperonins.

Proteins require a defined three-dimensional structure to fulfill central tasks in living organisms. Protein folding - the process in which they acquire their native structure - has been recognized as a spontaneous process. The three-dimensional structure is coded in the sequence of the building blocks, the amino acid. However, in the cellular environment proteins have to adopt their structure in a very short time after synthesis in the presence of a large number of other cellular components that could interfere with this process. Therefore a class of proteins, the chaperones, has evolved that rescues the folding intermediates from aggregation. A special kind of chaperones are double-ring, oligomeric containers, termed chaperonins. They provide closed compartments that shield folding proteins from the cellular environment.

According to their general importance chaperonins are present in all three kingdoms of life: eubacteria, archaea and eukaryotes. Based on their evolutionary relationship they fall into two distinct groups. The prototype of group I chaperonins is represented by GroEL which occurs in the eubacterium Escherichia coli. Group II chaperonins are comprised of the archaeal chaperonins, e.g. the thermosome of the present study, and the eukayotic CCT which occurs in higher organisms as human beings.

Members of both groups consume energy to drive the folding cycle by hydrolyzing ATP and share a basic principle of action. However, the implementation at th
'"/>

Contact: Robert Huber
huber@biochem.mpg.de
+49-89-85782678
Max-Planck-Gesellschaft
3-Apr-1998


Page: 1 2

Related biology news :

1. Crystal structure for anthrax-cell binding complex
2. Crystallographers take note: A synchrotron light source for your home lab
3. Crystal engineering helps scientists solve 3-D protein structures
4. Crystal structure of protein interaction could lead to new drugs against cancer
5. NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging DNA Molecules Into Two-Dimensional Crystals
6. Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
7. Space Grown Insulin Crystals Provide New Data On Diabetes
8. Biochemists Gain Crystal-Clear Insight into Ancient Enzyme
9. Liquid Crystals Light Up Simple Chemical Test
10. DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
11. Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 28, 2020 , ... ... interim results from their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will ... which will take place virtually on May 29th, 2020. Dr. Benedito Carneiro, Brown ...
(Date:5/21/2020)... ... May 19, 2020 , ... ... software-as-a-service (SaaS) provider of operations management solutions, today introduced BioMed to their ... a cloud-based platform for connecting the people and systems around biomedical engineering ...
(Date:5/15/2020)... FREDERICK, Md. (PRWEB) , ... May 15, 2020 , ... ... a boutique intellectual property law firm based in Frederick, Maryland and Tysons Corner, Virginia, ... the field of biotechnology and a another in the field of chemistry. The firm ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
(Date:6/23/2020)... Ariz. (PRWEB) , ... June 22, 2020 , ... ... is now offering an Amniosomes special offer. This includes buy three, get the ... should call (888) 568-6909. , Amniotic derived exosomes, known as exosomes, have been ...
(Date:6/11/2020)... ... June 08, 2020 , ... ... platform delivered through the use of proprietary clean viral vectors, recently announced a ... United States. Greffex’s platform is the world’s most successful gene therapy delivery ...
(Date:6/3/2020)... ... 03, 2020 , ... Thought Technology Ltd. is offering a ... installment, Dr. Inna Khazan will discuss the benefits of using mindfulness techniques with ... the feelings, thoughts, and emotions they are having in the present moment and ...
Breaking Biology Technology:
Cached News: