HOME >> BIOLOGY >> NEWS
Crystal structure for anthrax-cell binding complex

NOTE: This paper is being pulished early in an online edition.

(La Jolla, CA). A team of researchers led by The Burnham Institute's Robert C. Liddington has determined the crystal structure of the binding complex between anthrax toxin and one of its host receptors. Inhalation anthrax, unless diagnosed at a very early stage, is fatal: there is no existing antidote once the toxin is blood borne. The studies published by Liddington and colleagues on-line in the July 4th issue of Nature offer new leads for the discovery of anthrax antitoxins that could be used in conjunction with antibiotics to treat late-stage anthrax. In a surprising twist, the new information will also help in the design of anthrax toxin as an anti-tumor agent for treatment of cancer.

Anthrax toxin is comprised of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). To gain entry into host cells, PA must recognize a receptor on the surface of the target cell. Once PA has bound to the cell, it then enables EF and LF to bind and form a pore through which PA forces EF and LF into the cell in a syringe-like action.

Liddington's laboratory, together with Stephen Leppla at the National Institute of Allergy and Infectious Diseases, studied the interaction of PA with the two known receptors for anthrax: TEM8 and CMG2. PA binds tightly to both receptors and can use either to transfer toxicity into the cell. They were able to determine the crystal structure of the PA-CMG2 binding complex at atomic resolution, which makes it possible to design small molecules that will interact with PA and prevent the binding complex from forming. Soluble forms of the receptors have indeed acted as decoys, distracting PA from binding both receptors.

The two receptors are similar in how they mediate entry into the cells, but differ in important ways: The CMG2 receptor is present in most tissues, whereas the TEM8 receptor is mostly found on the
'"/>

Contact: Nancy Beddingfield
nbeddingfield@burnham.org
858-449-9940
Burnham Institute
4-Jul-2004


Page: 1 2

Related biology news :

1. Crystallographers take note: A synchrotron light source for your home lab
2. Crystal engineering helps scientists solve 3-D protein structures
3. Crystal structure of protein interaction could lead to new drugs against cancer
4. NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging DNA Molecules Into Two-Dimensional Crystals
5. Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
6. Space Grown Insulin Crystals Provide New Data On Diabetes
7. Biochemists Gain Crystal-Clear Insight into Ancient Enzyme
8. Crystal Structure Of The Archaeal Chaperonin Thermosome, A Protein-Folding Machine, Determined
9. Liquid Crystals Light Up Simple Chemical Test
10. DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
11. Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Crystal structure for anthrax cell binding complex

(Date:8/19/2014)... . Taking ... activity in children,Today the Canadian Society of Exercise Physiology ... activity and published their position and recommendations in the ... APNM ). This position stand provides an important ... physical activity for children and suggests both practical guidelines ...
(Date:8/19/2014)... Although body motion sensors already exist in different forms, ... complexity and cost of production. Now researchers from the ... the first time treated common elastic bands with graphene, ... for medical use and can be made cheaply. ... By fusing this material with graphene - which imparts ...
(Date:8/19/2014)... that protect their young have bigger brains than counterparts ... of British Columbia study. , Stickleback fish are well ... the male of the species, rather than the female, ... than females and researchers wanted to find out if ... as caregivers. , In the study, published recently ...
Breaking Biology News(10 mins):Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 3
(Date:8/18/2014)... NYElectronic devices with unprecedented efficiency and data ... that use built-in electric polarizations to read ... inside most popular data-driven technology. But ferroelectrics ... blocks, including a curious habit of "forgetting" ... the U.S. Department of Energy,s Brookhaven National ...
(Date:8/18/2014)... 18, 2014 Dyadic International, Inc. ("Dyadic") ... and proprietary technologies are used to develop, manufacture ... bioenergy, bio-based chemical, biopharmaceutical and industrial enzyme industries, ... Statement on Form 10 with the U.S. Securities ... - http://photos.prnewswire.com/prnh/20110621/CL06708LOGO The ...
(Date:8/16/2014)... physicists have found a way to make atomic-force microscope ... forces as small as the weight of an individual ... Australian National University (ANU), hinges on using laser beams ... Celsius. , "The level of sensitivity achieved after cooling ... of a large virus that is 100 billion times ...
(Date:8/15/2014)...  Two 5-foot-5 superbug-slaying machines were deployed from ... to JFK Hospital and ELWA Hospital in ... , where they will aid in the fight against ... - http://photos.prnewswire.com/prnh/20140814/136426 The devices, ... environments where Ebola patients are being treated. TRU-D is ...
Breaking Biology Technology:Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4Dyadic International Files Form 10 Registration Statement 2Dyadic International Files Form 10 Registration Statement 3Dyadic International Files Form 10 Registration Statement 4Laser makes microscopes way cooler 2Germ-Killing Robots Deployed to the Republic of Liberia To Aid in Battle Against Ebola Virus 2Germ-Killing Robots Deployed to the Republic of Liberia To Aid in Battle Against Ebola Virus 3
Cached News: