HOME >> BIOLOGY >> NEWS
Crystal structure for anthrax-cell binding complex

NOTE: This paper is being pulished early in an online edition.

(La Jolla, CA). A team of researchers led by The Burnham Institute's Robert C. Liddington has determined the crystal structure of the binding complex between anthrax toxin and one of its host receptors. Inhalation anthrax, unless diagnosed at a very early stage, is fatal: there is no existing antidote once the toxin is blood borne. The studies published by Liddington and colleagues on-line in the July 4th issue of Nature offer new leads for the discovery of anthrax antitoxins that could be used in conjunction with antibiotics to treat late-stage anthrax. In a surprising twist, the new information will also help in the design of anthrax toxin as an anti-tumor agent for treatment of cancer.

Anthrax toxin is comprised of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). To gain entry into host cells, PA must recognize a receptor on the surface of the target cell. Once PA has bound to the cell, it then enables EF and LF to bind and form a pore through which PA forces EF and LF into the cell in a syringe-like action.

Liddington's laboratory, together with Stephen Leppla at the National Institute of Allergy and Infectious Diseases, studied the interaction of PA with the two known receptors for anthrax: TEM8 and CMG2. PA binds tightly to both receptors and can use either to transfer toxicity into the cell. They were able to determine the crystal structure of the PA-CMG2 binding complex at atomic resolution, which makes it possible to design small molecules that will interact with PA and prevent the binding complex from forming. Soluble forms of the receptors have indeed acted as decoys, distracting PA from binding both receptors.

The two receptors are similar in how they mediate entry into the cells, but differ in important ways: The CMG2 receptor is present in most tissues, whereas the TEM8 receptor is mostly found on the
'"/>

Contact: Nancy Beddingfield
nbeddingfield@burnham.org
858-449-9940
Burnham Institute
4-Jul-2004


Page: 1 2

Related biology news :

1. Crystallographers take note: A synchrotron light source for your home lab
2. Crystal engineering helps scientists solve 3-D protein structures
3. Crystal structure of protein interaction could lead to new drugs against cancer
4. NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging DNA Molecules Into Two-Dimensional Crystals
5. Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
6. Space Grown Insulin Crystals Provide New Data On Diabetes
7. Biochemists Gain Crystal-Clear Insight into Ancient Enzyme
8. Crystal Structure Of The Archaeal Chaperonin Thermosome, A Protein-Folding Machine, Determined
9. Liquid Crystals Light Up Simple Chemical Test
10. DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
11. Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 /PRNewswire/ ... analysis of the bioinformatic market by reviewing the ... computer enabled tools that drive the field forward. ... report to: Identify the challenges and opportunities ... service providers and software solution developers, as well ...
(Date:2/2/2016)... Feb. 2, 2016   Parabon NanoLabs ... U.S. Army Research Office and the Defense Forensics ... sensitivity of the company,s Snapshot Kinship Inference ... and, more generally, defense-related DNA forensics.  Although Snapshot ... (predicting appearance and ancestry from DNA evidence), it ...
(Date:2/1/2016)... NEW YORK , Feb. 1, 2016  Today, ... Heart Association (AHA) announced plans to develop a first ... cognitive computing power of IBM Watson. In the first ... disease, AHA, IBM (NYSE: IBM ), and Welltok ... metrics and health assessments with cognitive analytics, delivered on ...
Breaking Biology News(10 mins):
(Date:2/11/2016)...  Bioethics International, a not-for-profit organization focused on the ethics ... made accessible to patients around the world, today announced that ... publication of the Good Pharma Scorecard an ... as one of BMJ Open ,s ,Most Popular Articles, ... most frequently read. Ed Sucksmith , assistant editor ...
(Date:2/11/2016)... 11, 2016  Dovetail Genomics™ LLC today announced that ... for a planned metagenomic genome assembly service. Richard ... genome assembly method in a talk on Friday, February ... Technology conference in Orlando, Fla. ... datasets is difficult. Using its proprietary Chicago ...
(Date:2/11/2016)... ... 11, 2016 , ... Global Stem Cells Group, ... Global Stem Cells Network (GSCN) to distribute exosome injection and other biological products ... Costa Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, Peru, Ecuador, ...
(Date:2/10/2016)... 10, 2016  The Maryland House of Delegates and ... that University of Maryland School of Medicine Dean ... of Maryland Medical System President and CEO Robert ... the highest honor given to the public by the ... Dean Reece and Mr. Chrencik for their contributions ...
Breaking Biology Technology:
Cached News: