HOME >> BIOLOGY >> NEWS
Crystal structure for anthrax-cell binding complex

NOTE: This paper is being pulished early in an online edition.

(La Jolla, CA). A team of researchers led by The Burnham Institute's Robert C. Liddington has determined the crystal structure of the binding complex between anthrax toxin and one of its host receptors. Inhalation anthrax, unless diagnosed at a very early stage, is fatal: there is no existing antidote once the toxin is blood borne. The studies published by Liddington and colleagues on-line in the July 4th issue of Nature offer new leads for the discovery of anthrax antitoxins that could be used in conjunction with antibiotics to treat late-stage anthrax. In a surprising twist, the new information will also help in the design of anthrax toxin as an anti-tumor agent for treatment of cancer.

Anthrax toxin is comprised of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). To gain entry into host cells, PA must recognize a receptor on the surface of the target cell. Once PA has bound to the cell, it then enables EF and LF to bind and form a pore through which PA forces EF and LF into the cell in a syringe-like action.

Liddington's laboratory, together with Stephen Leppla at the National Institute of Allergy and Infectious Diseases, studied the interaction of PA with the two known receptors for anthrax: TEM8 and CMG2. PA binds tightly to both receptors and can use either to transfer toxicity into the cell. They were able to determine the crystal structure of the PA-CMG2 binding complex at atomic resolution, which makes it possible to design small molecules that will interact with PA and prevent the binding complex from forming. Soluble forms of the receptors have indeed acted as decoys, distracting PA from binding both receptors.

The two receptors are similar in how they mediate entry into the cells, but differ in important ways: The CMG2 receptor is present in most tissues, whereas the TEM8 receptor is mostly found on the
'"/>

Contact: Nancy Beddingfield
nbeddingfield@burnham.org
858-449-9940
Burnham Institute
4-Jul-2004


Page: 1 2

Related biology news :

1. Crystallographers take note: A synchrotron light source for your home lab
2. Crystal engineering helps scientists solve 3-D protein structures
3. Crystal structure of protein interaction could lead to new drugs against cancer
4. NYU Researchers Develop Simple, Predictable And Precise Technique For Arranging DNA Molecules Into Two-Dimensional Crystals
5. Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
6. Space Grown Insulin Crystals Provide New Data On Diabetes
7. Biochemists Gain Crystal-Clear Insight into Ancient Enzyme
8. Crystal Structure Of The Archaeal Chaperonin Thermosome, A Protein-Folding Machine, Determined
9. Liquid Crystals Light Up Simple Chemical Test
10. DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
11. Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Crystal structure for anthrax cell binding complex

(Date:7/23/2014)... has the nasty habit of getting tangled and forming ... and learn how to disentangle them (e.g. useful for ... School for Advanced Studies (SISSA) in Trieste and his ... simulate these knots and their dynamics. In their latest ... , Micheletti together with Marco Di Stefano, first author ...
(Date:7/23/2014)... is available in German . ... modalities for orientation, some of which might be very ... the polarization pattern produced by sunlight in the atmosphere ... Max Planck Institute for Ornithology in Seewiesen, Germany, and ... that a night active mammal, the greater mouse-eared bat, ...
(Date:7/23/2014)... Currently, no cure exists for Alzheimer,s disease, the ... Americans. But scientists are now reporting new progress ... cancer treatment, that shows promise as a potential ... ACS, Journal of Medicinal Chemistry . , ... that in a healthy brain, the protein known ...
Breaking Biology News(10 mins):Bats use the evening sky's polarization pattern for orientation 2
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer ... cosmetics, and other markets, announced today that it has ... qualified private investors led by Novit L.P., an investment ... transaction involved the signing of a Securities Purchase Agreement ... Stock at a price per share of $1.00, resulting ...
(Date:7/22/2014)... Lake, Wisconsin (PRWEB) July 22, 2014 ... be in attendance at the 2014 NCSL International ... Booth #423 will feature CONDEC pressure instrumentation, ... style weights, and the new, customized sets, Essential ... ago to promote cooperative efforts in solving the ...
(Date:7/22/2014)... 22, 2014 Two new members were ... Directors at its annual Shareholders Meeting on June 13: ... of The PFM Group, and Stephen T. Zarrilli, President ... announced the election of Michael A. DiPiano, Managing General ... and Richard P. Jaffe, Esq., of Duane Morris LLP, ...
(Date:7/22/2014)... 2014  Neogen Corporation (NASDAQ: NEOG ) ... which ended May 31, increased 19% from the previous ... compared to the prior year,s $27,190,000. Adjusted for a ... share in the current year were $0.76, compared to ... for the 2014 fiscal year established new all-time highs ...
Breaking Biology Technology:CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3Neogen reports 19% increase in annual revenues 2Neogen reports 19% increase in annual revenues 3Neogen reports 19% increase in annual revenues 4Neogen reports 19% increase in annual revenues 5Neogen reports 19% increase in annual revenues 6Neogen reports 19% increase in annual revenues 7Neogen reports 19% increase in annual revenues 8
Cached News: