Crystallographers take note: A synchrotron light source for your home lab

A new technological development promises to shed light--synchrotron light, that is--on structural genomics. Crystallographers will soon be able to perform state-of-the-art protein structure determination in their own laboratory with a new miniature synchrotron light source capable of producing high-intensity, tunable, near-monochromatic X-rays. This tabletop device, the Compact Light Source, will soon bring high-flux, high-quality X-rays directly to the university or industrial laboratory--and one day to the hospital or clinic.

Today at the Keystone Symposia on Structural Genomics in Snowbird, Utah, Ronald Ruth, Ph.D., president of Lyncean Technologies, Inc., announced the construction of a tabletop synchrotron light source that will be tested early in 2005. The prototype development is supported by the Protein Structure Initiative of the National Institute of General Medical Sciences (NIGMS) and is based on licensed technology from Stanford Linear Accelerator Center (SLAC).

During the past 30 years, synchrotron light sources have become the X-ray probe of choice for physicists, chemists, biologists and research physicians. With their high-quality, intense X-ray beams, a handful of national synchrotron laboratories have revolutionized X-ray science and spawned a large number of new technologies. The most striking examples of the impact of synchrotron light come from the three-dimensional studies of protein structure.

The Compact Light Source is one of the technology development projects funded for its potential contribution to the NIGMS Protein Structure Initiative (PSI).

"We launched the PSI in 2000 as an ambitious, 10-year project to dramatically reduce the time and cost of solving protein structures," said PSI director John Norvell, Ph.D. "With PSI support, scientists around the world are using highly automated systems to determine the structures of thousands of proteins experimentally and produce computer-based tools for ulti

Contact: Ronald Ruth
Lyncean Technologies, Inc.

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